FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227263789> ?p ?o ?g. }

• W2227263789 endingPage "272" @default.
• W2227263789 startingPage "264" @default.
• W2227263789 abstract "Colloidal silver nanoparticles (AgNPs) have attracted much attention in recent years as diagnostics and new drug delivery system in cancer medicine. To study the effects of plumbagin (PLB), a relatively non-toxic napthaquinone isolated from the roots of Plumbago indica in human cervical cancer cell line and developed a formulation to enhance its cytotoxic activities. Silver nanoparticles were synthesised by chemical reduction method and complexed with PLB. Both the AgNPs and the complex PLB-AgNPs were characterised by dynamic light scattering, high-resolution scanning electron microscopy and transmission electron microscopy. The amount of PLB and PLB-AgNPs internalised was determined by ultra-violet-visible spectrophotometer. Cell inhibition was determined by sulphorhodamine B assay. Mitotic index was determined by Wright-Giemsa staining. Apoptosis induction was assessed by western blot using cleaved poly adenosine diphosphate-ribose polymerase antibody. The scanning electron microscope analysis indicated an average particle size of 32±8 nm in diameter. Enhanced internalisation of PLB into the HeLa cells was observed in PLB-AgNPs. PLB inhibited proliferation of cells with IC50 value of about 18±0.6 µM and blocked the cells at mitosis in a concentration-dependent manner. PLB also inhibited the post-drug exposure clonogenic survival of cells and induced apoptosis. The antiproliferative, antimitotic and apoptotic activities were also found to be increased when cells were treated with PLB-AgNPs. The authors results support the idea that AgNP could be a promising and effective drug delivery system for enhanced activity of PLB in cancer treatment." @default.
• W2227263789 created "2016-06-24" @default.
• W2227263789 creator A5083618667 @default.
• W2227263789 creator A5089878749 @default.
• W2227263789 date "2015-10-01" @default.
• W2227263789 modified "2023-10-03" @default.
• W2227263789 title "Plumbagin‐silver nanoparticle formulations enhance the cellular uptake of plumbagin and its antiproliferative activities" @default.
• W2227263789 cites W1264540065 @default.
• W2227263789 cites W1558305967 @default.
• W2227263789 cites W1804758906 @default.
• W2227263789 cites W1952221220 @default.
• W2227263789 cites W1965549147 @default.
• W2227263789 cites W1966264377 @default.
• W2227263789 cites W1982258251 @default.
• W2227263789 cites W1986298455 @default.
• W2227263789 cites W1997442847 @default.
• W2227263789 cites W2001544973 @default.
• W2227263789 cites W2002060477 @default.
• W2227263789 cites W2009891872 @default.
• W2227263789 cites W2026469410 @default.
• W2227263789 cites W2026606823 @default.
• W2227263789 cites W2047219204 @default.
• W2227263789 cites W2055312279 @default.
• W2227263789 cites W2058903721 @default.
• W2227263789 cites W2066354221 @default.
• W2227263789 cites W2068091781 @default.
• W2227263789 cites W2070360811 @default.
• W2227263789 cites W2075408635 @default.
• W2227263789 cites W2076038104 @default.
• W2227263789 cites W2077611484 @default.
• W2227263789 cites W2095248480 @default.
• W2227263789 cites W2096358571 @default.
• W2227263789 cites W2100032465 @default.
• W2227263789 cites W2100931314 @default.
• W2227263789 cites W2101809587 @default.
• W2227263789 cites W2104154679 @default.
• W2227263789 cites W2106657483 @default.
• W2227263789 cites W2118234018 @default.
• W2227263789 cites W2136846371 @default.
• W2227263789 cites W2141449020 @default.
• W2227263789 cites W2141682838 @default.
• W2227263789 cites W2146194090 @default.
• W2227263789 cites W2148051364 @default.
• W2227263789 cites W2155664984 @default.
• W2227263789 cites W2156251634 @default.
• W2227263789 cites W4293247451 @default.
• W2227263789 doi "https://doi.org/10.1049/iet-nbt.2015.0008" @default.
• W2227263789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26435279" @default.
• W2227263789 hasPublicationYear "2015" @default.
• W2227263789 type Work @default.
• W2227263789 sameAs 2227263789 @default.
• W2227263789 citedByCount "23" @default.
• W2227263789 countsByYear W22272637892016 @default.
• W2227263789 countsByYear W22272637892017 @default.
• W2227263789 countsByYear W22272637892018 @default.
• W2227263789 countsByYear W22272637892019 @default.
• W2227263789 countsByYear W22272637892020 @default.
• W2227263789 countsByYear W22272637892021 @default.
• W2227263789 countsByYear W22272637892022 @default.
• W2227263789 countsByYear W22272637892023 @default.
• W2227263789 crossrefType "journal-article" @default.
• W2227263789 hasAuthorship W2227263789A5083618667 @default.
• W2227263789 hasAuthorship W2227263789A5089878749 @default.
• W2227263789 hasBestOaLocation W22272637891 @default.
• W2227263789 hasConcept C109316439 @default.
• W2227263789 hasConcept C121608353 @default.
• W2227263789 hasConcept C12554922 @default.
• W2227263789 hasConcept C13965031 @default.
• W2227263789 hasConcept C14631669 @default.
• W2227263789 hasConcept C1491633281 @default.
• W2227263789 hasConcept C153911025 @default.
• W2227263789 hasConcept C155672457 @default.
• W2227263789 hasConcept C171250308 @default.
• W2227263789 hasConcept C185592680 @default.
• W2227263789 hasConcept C190283241 @default.
• W2227263789 hasConcept C192562407 @default.
• W2227263789 hasConcept C202751555 @default.
• W2227263789 hasConcept C2776375370 @default.
• W2227263789 hasConcept C2777366897 @default.
• W2227263789 hasConcept C2780532915 @default.
• W2227263789 hasConcept C29537977 @default.
• W2227263789 hasConcept C31499863 @default.
• W2227263789 hasConcept C54355233 @default.
• W2227263789 hasConcept C55493867 @default.
• W2227263789 hasConcept C86803240 @default.
• W2227263789 hasConcept C96232424 @default.
• W2227263789 hasConceptScore W2227263789C109316439 @default.
• W2227263789 hasConceptScore W2227263789C121608353 @default.
• W2227263789 hasConceptScore W2227263789C12554922 @default.
• W2227263789 hasConceptScore W2227263789C13965031 @default.
• W2227263789 hasConceptScore W2227263789C14631669 @default.
• W2227263789 hasConceptScore W2227263789C1491633281 @default.
• W2227263789 hasConceptScore W2227263789C153911025 @default.
• W2227263789 hasConceptScore W2227263789C155672457 @default.
• W2227263789 hasConceptScore W2227263789C171250308 @default.
• W2227263789 hasConceptScore W2227263789C185592680 @default.
• W2227263789 hasConceptScore W2227263789C190283241 @default.
• W2227263789 hasConceptScore W2227263789C192562407 @default.

• next