Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227307923> ?p ?o ?g. }
- W2227307923 endingPage "e0142157" @default.
- W2227307923 startingPage "e0142157" @default.
- W2227307923 abstract "Pinus massoniana bark proanthocyanidins (PMBPs), an active component isolated from Pinus massoniana bark, has been reported to possess a wide range of biochemical properties. Here, we investigated the anti-tumor effect of PMBPs on ovarian cancer. The results indicated that PMBPs significantly reduced the growth of ovarian cancer cells and induced dose-dependent apoptosis. The underlying mechanisms involved were elucidated to include the loss of mitochondrial membrane potential, down-regulation of the anti-apoptotic protein Bcl-2 and the activation of Caspase 3/9, suggesting that PMBPs triggered apoptosis through activation of mitochondria-associated apoptotic pathway. In addition, wound healing and transwell chamber assays revealed that PMBPs could suppress migration and invasion of ovarian cancer cells. PMBPs dramatically inhibited MMP-9 activity and expression, blocked the activity of NFκB and the activation of ERK1/2 and p38 MAPK. Our findings suggest that PMBPs has the potential to be developed as an anti-tumor drug for ovarian cancer treatment and/ or disease management." @default.
- W2227307923 created "2016-06-24" @default.
- W2227307923 creator A5005400963 @default.
- W2227307923 creator A5008921533 @default.
- W2227307923 creator A5021150663 @default.
- W2227307923 creator A5036397083 @default.
- W2227307923 creator A5037677450 @default.
- W2227307923 creator A5043934356 @default.
- W2227307923 creator A5052386069 @default.
- W2227307923 creator A5059834466 @default.
- W2227307923 creator A5063546301 @default.
- W2227307923 date "2015-11-05" @default.
- W2227307923 modified "2023-09-25" @default.
- W2227307923 title "Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration" @default.
- W2227307923 cites W1540591943 @default.
- W2227307923 cites W1578523240 @default.
- W2227307923 cites W1807491301 @default.
- W2227307923 cites W1830713541 @default.
- W2227307923 cites W1965676791 @default.
- W2227307923 cites W1966932597 @default.
- W2227307923 cites W1971518346 @default.
- W2227307923 cites W1973612882 @default.
- W2227307923 cites W1976560584 @default.
- W2227307923 cites W1976606354 @default.
- W2227307923 cites W1977063445 @default.
- W2227307923 cites W1990065094 @default.
- W2227307923 cites W1990698300 @default.
- W2227307923 cites W1991460671 @default.
- W2227307923 cites W1991879475 @default.
- W2227307923 cites W1992912936 @default.
- W2227307923 cites W2005771407 @default.
- W2227307923 cites W2022034924 @default.
- W2227307923 cites W2046830304 @default.
- W2227307923 cites W2067329503 @default.
- W2227307923 cites W2068321971 @default.
- W2227307923 cites W2069416400 @default.
- W2227307923 cites W2071048538 @default.
- W2227307923 cites W2078822667 @default.
- W2227307923 cites W2093662470 @default.
- W2227307923 cites W2117803941 @default.
- W2227307923 cites W2121318534 @default.
- W2227307923 cites W2127787692 @default.
- W2227307923 cites W2129038883 @default.
- W2227307923 cites W2129490943 @default.
- W2227307923 cites W2137091088 @default.
- W2227307923 cites W2139564145 @default.
- W2227307923 cites W2155816561 @default.
- W2227307923 cites W2159776676 @default.
- W2227307923 cites W2162991774 @default.
- W2227307923 cites W2163101003 @default.
- W2227307923 cites W2164277862 @default.
- W2227307923 cites W2412090798 @default.
- W2227307923 cites W2418653953 @default.
- W2227307923 cites W904590016 @default.
- W2227307923 doi "https://doi.org/10.1371/journal.pone.0142157" @default.
- W2227307923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4634942" @default.
- W2227307923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26539720" @default.
- W2227307923 hasPublicationYear "2015" @default.
- W2227307923 type Work @default.
- W2227307923 sameAs 2227307923 @default.
- W2227307923 citedByCount "19" @default.
- W2227307923 countsByYear W22273079232016 @default.
- W2227307923 countsByYear W22273079232017 @default.
- W2227307923 countsByYear W22273079232018 @default.
- W2227307923 countsByYear W22273079232019 @default.
- W2227307923 countsByYear W22273079232020 @default.
- W2227307923 countsByYear W22273079232021 @default.
- W2227307923 countsByYear W22273079232022 @default.
- W2227307923 countsByYear W22273079232023 @default.
- W2227307923 crossrefType "journal-article" @default.
- W2227307923 hasAuthorship W2227307923A5005400963 @default.
- W2227307923 hasAuthorship W2227307923A5008921533 @default.
- W2227307923 hasAuthorship W2227307923A5021150663 @default.
- W2227307923 hasAuthorship W2227307923A5036397083 @default.
- W2227307923 hasAuthorship W2227307923A5037677450 @default.
- W2227307923 hasAuthorship W2227307923A5043934356 @default.
- W2227307923 hasAuthorship W2227307923A5052386069 @default.
- W2227307923 hasAuthorship W2227307923A5059834466 @default.
- W2227307923 hasAuthorship W2227307923A5063546301 @default.
- W2227307923 hasBestOaLocation W22273079231 @default.
- W2227307923 hasConcept C121608353 @default.
- W2227307923 hasConcept C185592680 @default.
- W2227307923 hasConcept C190283241 @default.
- W2227307923 hasConcept C2780427987 @default.
- W2227307923 hasConcept C502942594 @default.
- W2227307923 hasConcept C51551487 @default.
- W2227307923 hasConcept C54355233 @default.
- W2227307923 hasConcept C55493867 @default.
- W2227307923 hasConcept C57074206 @default.
- W2227307923 hasConcept C62112901 @default.
- W2227307923 hasConcept C62478195 @default.
- W2227307923 hasConcept C86803240 @default.
- W2227307923 hasConcept C95444343 @default.
- W2227307923 hasConcept C98274493 @default.
- W2227307923 hasConceptScore W2227307923C121608353 @default.
- W2227307923 hasConceptScore W2227307923C185592680 @default.
- W2227307923 hasConceptScore W2227307923C190283241 @default.
- W2227307923 hasConceptScore W2227307923C2780427987 @default.