FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227358508> ?p ?o ?g. }

• W2227358508 abstract "Severity of illness is an important consideration in making the decision to transfuse as it is the sicker patient that often needs a red cell transfusion. Red blood cell (RBC) transfusions could potentially have direct effects and interact with presenting illness by contributing to pathologies such as multi-organ dysfunction and acute lung injury thus exerting a considerable impact on overall morbidity and mortality. In this study, we examine if transfusion is an independent predictor of mortality, or if outcomes are merely a result of the initial severity as predicted by Pediatric Risk of Mortality (PRISM) III, Pediatric Index of Mortality (PIM2), and day 1 Pediatric Logistic Organ Dysfunction (PELOD) scores. A single center retrospective study was conducted using data from a prospectively maintained transfusion database and center-specific data at our pediatric ICU between January 2009 and December 2012. Multivariate regression was used to control for the effects of clinical findings, therapy, and severity scores, with mortality as the dependent variable. Likelihood ratios and area under the curve were used to test the fidelity of severity scores by comparing transfused vs. non-transfused patients. There were 4975 admissions that met entry criteria. In multivariate analysis, PRISM III scores and serum hemoglobin were significant predictors of transfusion (p < 0.05). Transfused and non-transfused subjects were distinctly disparate, so multivariate regression was used to control for differences. Severity scores, age, volume transfused, and vasoactive agents were significantly associated with mortality whereas hemoglobin was not. A substantial number of transfusions (45 %) occurred in the first 24 h, and patients transfused later (24–48 h) were more likely to die compared to this earlier time point. Likelihood ratio testing revealed statistically significant differences in severity scoring systems to predict mortality in transfused vs. non-transfused patients. This study suggests that RBC transfusion is an important risk factor that is statistically independent of severity. The timing of transfusions that related strongest to mortality remained outside the purview of severity scoring, as these happened beyond the timing of data collection for most scoring systems." @default.
• W2227358508 created "2016-06-24" @default.
• W2227358508 creator A5003333475 @default.
• W2227358508 creator A5009052087 @default.
• W2227358508 creator A5019939988 @default.
• W2227358508 creator A5021054078 @default.
• W2227358508 creator A5045281698 @default.
• W2227358508 creator A5057454162 @default.
• W2227358508 creator A5058413141 @default.
• W2227358508 creator A5063844077 @default.
• W2227358508 creator A5065933660 @default.
• W2227358508 creator A5069288617 @default.
• W2227358508 creator A5079515340 @default.
• W2227358508 date "2016-01-07" @default.
• W2227358508 modified "2023-10-13" @default.
• W2227358508 title "Red cell transfusions as an independent risk for mortality in critically ill children" @default.
• W2227358508 cites W1538170740 @default.
• W2227358508 cites W1540836442 @default.
• W2227358508 cites W1574141134 @default.
• W2227358508 cites W1979610312 @default.
• W2227358508 cites W1981809616 @default.
• W2227358508 cites W1987442085 @default.
• W2227358508 cites W1994801698 @default.
• W2227358508 cites W2002926363 @default.
• W2227358508 cites W2003377442 @default.
• W2227358508 cites W200405971 @default.
• W2227358508 cites W2006115390 @default.
• W2227358508 cites W2007320066 @default.
• W2227358508 cites W2023773410 @default.
• W2227358508 cites W2031511977 @default.
• W2227358508 cites W2051900052 @default.
• W2227358508 cites W2059273647 @default.
• W2227358508 cites W2062251324 @default.
• W2227358508 cites W2070735691 @default.
• W2227358508 cites W2073890129 @default.
• W2227358508 cites W2078408849 @default.
• W2227358508 cites W2079184351 @default.
• W2227358508 cites W2084445380 @default.
• W2227358508 cites W2090125872 @default.
• W2227358508 cites W2096648582 @default.
• W2227358508 cites W2106824578 @default.
• W2227358508 cites W2112525092 @default.
• W2227358508 cites W2130644475 @default.
• W2227358508 cites W2133034712 @default.
• W2227358508 cites W2138697408 @default.
• W2227358508 cites W2156870897 @default.
• W2227358508 cites W2163034869 @default.
• W2227358508 cites W2415998755 @default.
• W2227358508 doi "https://doi.org/10.1186/s40560-015-0122-3" @default.
• W2227358508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704419" @default.
• W2227358508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26744626" @default.
• W2227358508 hasPublicationYear "2016" @default.
• W2227358508 type Work @default.
• W2227358508 sameAs 2227358508 @default.
• W2227358508 citedByCount "27" @default.
• W2227358508 countsByYear W22273585082016 @default.
• W2227358508 countsByYear W22273585082017 @default.
• W2227358508 countsByYear W22273585082018 @default.
• W2227358508 countsByYear W22273585082019 @default.
• W2227358508 countsByYear W22273585082020 @default.
• W2227358508 countsByYear W22273585082021 @default.
• W2227358508 countsByYear W22273585082022 @default.
• W2227358508 countsByYear W22273585082023 @default.
• W2227358508 crossrefType "journal-article" @default.
• W2227358508 hasAuthorship W2227358508A5003333475 @default.
• W2227358508 hasAuthorship W2227358508A5009052087 @default.
• W2227358508 hasAuthorship W2227358508A5019939988 @default.
• W2227358508 hasAuthorship W2227358508A5021054078 @default.
• W2227358508 hasAuthorship W2227358508A5045281698 @default.
• W2227358508 hasAuthorship W2227358508A5057454162 @default.
• W2227358508 hasAuthorship W2227358508A5058413141 @default.
• W2227358508 hasAuthorship W2227358508A5063844077 @default.
• W2227358508 hasAuthorship W2227358508A5065933660 @default.
• W2227358508 hasAuthorship W2227358508A5069288617 @default.
• W2227358508 hasAuthorship W2227358508A5079515340 @default.
• W2227358508 hasBestOaLocation W22273585081 @default.
• W2227358508 hasConcept C105795698 @default.
• W2227358508 hasConcept C126322002 @default.
• W2227358508 hasConcept C151956035 @default.
• W2227358508 hasConcept C161584116 @default.
• W2227358508 hasConcept C167135981 @default.
• W2227358508 hasConcept C177713679 @default.
• W2227358508 hasConcept C194828623 @default.
• W2227358508 hasConcept C2777984932 @default.
• W2227358508 hasConcept C2778384902 @default.
• W2227358508 hasConcept C2778426790 @default.
• W2227358508 hasConcept C30036603 @default.
• W2227358508 hasConcept C33923547 @default.
• W2227358508 hasConcept C38180746 @default.
• W2227358508 hasConcept C71924100 @default.
• W2227358508 hasConceptScore W2227358508C105795698 @default.
• W2227358508 hasConceptScore W2227358508C126322002 @default.
• W2227358508 hasConceptScore W2227358508C151956035 @default.
• W2227358508 hasConceptScore W2227358508C161584116 @default.
• W2227358508 hasConceptScore W2227358508C167135981 @default.
• W2227358508 hasConceptScore W2227358508C177713679 @default.
• W2227358508 hasConceptScore W2227358508C194828623 @default.
• W2227358508 hasConceptScore W2227358508C2777984932 @default.
• W2227358508 hasConceptScore W2227358508C2778384902 @default.
• W2227358508 hasConceptScore W2227358508C2778426790 @default.

• next