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• W222739660 abstract "Background. Older adults have higher mortality rates after severe traumatic brain injury (TBI) compared to younger adults. Brain-derived neurotrophic factor (BDNF) signaling is altered in aging and is important to TBI given its role in neuronal survival/plasticity and autonomic function. Following experimental TBI, acute BDNF administration has not been efficacious. Clinically, genetic variation in BDNF (reduced signaling alleles: rs6265, Met-carriers; rs7124442, C-carriers) can be protective against acute mortality. Postacutely, these genotypes carry lower mortality risk in older adults and greater mortality risk among younger adults. Objective. Investigate BDNF levels in mortality/outcome following severe TBI in the context of age and genetic risk. Methods. Cerebrospinal fluid (CSF) and serum BDNF were assessed prospectively during the first week following severe TBI (n = 203) and in controls (n = 10). Age, BDNF genotype, and BDNF levels were assessed as mortality/outcome predictors. Results. CSF BDNF levels tended to be higher post-TBI ( P = .061) versus controls and were associated with time until death ( P = .042). In contrast, serum BDNF levels were reduced post-TBI versus controls ( P < .0001). Both gene * BDNF serum and gene * age interactions were mortality predictors post-TBI in the same multivariate model. CSF and serum BDNF tended to be negatively correlated post-TBI ( P = .07). Conclusions. BDNF levels predicted mortality, in addition to gene * age interactions, suggesting levels capture additional mortality risk. Higher CSF BDNF post-TBI may be detrimental due to injury and age-related increases in pro-apoptotic BDNF target receptors. Negative CSF and serum BDNF correlations post-TBI suggest blood–brain barrier transit alterations. Understanding BDNF signaling in neuronal survival, plasticity, and autonomic function may inform treatment." @default.
• W222739660 created "2016-06-24" @default.
• W222739660 creator A5013561770 @default.
• W222739660 creator A5016803157 @default.
• W222739660 creator A5039442562 @default.
• W222739660 date "2015-05-15" @default.
• W222739660 modified "2023-10-17" @default.
• W222739660 title "Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury–Related Mortality" @default.
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• W222739660 doi "https://doi.org/10.1177/1545968315586465" @default.
• W222739660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4644728" @default.
• W222739660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25979196" @default.
• W222739660 hasPublicationYear "2015" @default.
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