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• W2227408774 abstract "Apolipoprotein E (apoE) is a well characterized lipophilic protein associated with plasma and CSF lipoproteins. ApoE is synthesized primarily by the liver, but also at other sites including brain, macrophages and adrenals. Furthermore, apoE is unique among apolipoproteins in that it has a special relevance to the central and peripheral nervous systems. It is a key determinant in the cellular recognition and internalization of cholesterol- and phospholipid-rich lipoproteins in the developing brain and in the response to neuronal injury (Boyles et al., 1989, Poirier et al., 1991, 1991a, 1993). It was shown to play a fundamental role in the CNS during hippocampal synaptic plasticity induced by entorhinal cortex lesions in the rat (Poirier et al., 1991, 1991a and 1993)." @default.
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• W2227408774 date "1997-01-01" @default.
• W2227408774 modified "2023-09-27" @default.
• W2227408774 title "Apolipoprotein E4 and Cholinergic Activity in Alzheimer’s Disease" @default.
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• W2227408774 doi "https://doi.org/10.1007/978-1-4612-4116-4_9" @default.
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