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- W22274404 abstract "This chapter describes the biliary metabolites of benzo(a)pyrene (BP). The initial step in the metabolic activation of BP is the conversion to arene oxides, which may be further metabolized to ultimate carcinogens, such as diol epoxides, or to non-carcinogenic metabolites. The biotransformation pathways for intermediate arene oxides are, therefore, important in determining whether activation or detoxication occurs. The interest in the fate of reactive metabolites and the role of the glutathione 5-transferases in their detoxication led to investigate the biliary metabolites of benzo(a)pyrene 4, 5-oxide (BPO) in the rat. Previous studies of BP metabolism have focused on the solvent-extractable metabolites such as phenols, quinones, and dihydrodiols. However, the water-soluble metabolites have been less extensively investigated. As thioether conjugates arising from the reaction of arene oxides with glutathione are indicative of detoxication, more attention should be paid to the compounds of this type." @default.
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- W22274404 date "1980-01-01" @default.
- W22274404 modified "2023-09-23" @default.
- W22274404 title "BILIARY METABOLITES OF BENZO(a)PYRENE 4,5-OXIDE IN THE RAT" @default.
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- W22274404 doi "https://doi.org/10.1016/b978-0-12-187702-6.50013-x" @default.
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