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- W2227478911 abstract "AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA260 Glioblastoma, the most aggressive and least treatable form of malignant glioma, is the most common human brain tumor. Although many regions of allelic loss occur in glioblastomas, relatively few tumor suppressor genes have been found mutated at such loci.The methylation status of MGMT has previously been shown to be closely linked to treatment outcome in brain tumors indicating an epigenetic involvement in the pathology of these tumors. We recently published a study in which we exposed triplicates of three short-term cultured glioblastomas to 5μM 5-aza-dC for 96 hours followed by cRNA hybridization to an oligonucleotide microarray (Affymetrix U133A). The results identified RUNX and TES as two genes with altered methylation patterns in glioblastoma.Here we present quantitative methylation data for a set of 16 additional genes. We used a novel method based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to perform large-scale quantitative methylation profiling. We found 4 genes to have identical methylation patterns between normal and tumor cell lines, 13 showed hypermethylation in glioblastoma cell lines and 1 gene showed hypomethylation. We also show a correlation between differential methylation and gene expression changes.The results shown here indicate a strong bias towards hypermethylation in glioblastoma cell lines. This bias should initiate further validation of non-cell line samples, validating epigenetic disregulation as an essential biological process in malignant glioma progression." @default.
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- W2227478911 date "2007-05-01" @default.
- W2227478911 modified "2023-09-23" @default.
- W2227478911 title "Identification of tumor suppressor genes by large-scale profiling of cytosine-methylation in glioblastoma cell lines" @default.
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