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- W2227480827 abstract "Antisense oligonucleotides (ASOs) have a great therapeutic potential for the modulation of gene expression because of the high specificity. The major obstacles for clinical application are enzymatic degradation and low uptake into cells in vivo. In this study, we prepared the conjugate comprising Tat peptide and ASO with phosphorothioate linkages in a simple manner; azide alkyne Huisgen cycloaddition using a copper catalyst. The obtained conjugate showed a high stability in serum, compared with the conjugate with phosphodiester linkages. The conjugates with antisense for c-myb that is transcriptional factor concerning cell growth inhibited the cell proliferation in a dose dependent manner sequence-specifically. These findings suggest Tat-mediated ASOs delivery is useful for the treatment of various diseases." @default.
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- W2227480827 date "2016-02-01" @default.
- W2227480827 modified "2023-09-24" @default.
- W2227480827 title "Gene silencing using a conjugate comprising Tat peptide and antisense oligonucleotide with phosphorothioate backbones" @default.
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- W2227480827 doi "https://doi.org/10.1016/j.bmcl.2016.01.018" @default.
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