FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227501619> ?p ?o ?g. }

• W2227501619 endingPage "1372" @default.
• W2227501619 startingPage "1364" @default.
• W2227501619 abstract "Most airway diseases, including chronic obstructive pulmonary disease (COPD), are associated with excessive coughing. The extent to which this may be a consequence of increased activation of vagal afferents by pathology in the airways (e.g., inflammatory mediators, excessive mucus) or an altered neuronal phenotype is unknown. Understanding whether respiratory diseases are associated with dysfunction of airway sensory nerves has the potential to identify novel therapeutic targets.To assess the changes in cough responses to a range of inhaled irritants in COPD and model these in animals to investigate the underlying mechanisms.Cough responses to inhaled stimuli in patients with COPD, healthy smokers, refractory chronic cough, asthma, and healthy volunteers were assessed and compared with vagus/airway nerve and cough responses in a cigarette smoke (CS) exposure guinea pig model.Patients with COPD had heightened cough responses to capsaicin but reduced responses to prostaglandin E2 compared with healthy volunteers. Furthermore, the different patient groups all exhibited different patterns of modulation of cough responses. Consistent with these findings, capsaicin caused a greater number of coughs in CS-exposed guinea pigs than in control animals; similar increased responses were observed in ex vivo vagus nerve and neuron cell bodies in the vagal ganglia. However, responses to prostaglandin E2 were decreased by CS exposure.CS exposure is capable of inducing responses consistent with phenotypic switching in airway sensory nerves comparable with the cough responses observed in patients with COPD. Moreover, the differing profiles of cough responses support the concept of disease-specific neurophenotypes in airway disease. Clinical trial registered with www.clinicaltrials.gov (NCT 01297790)." @default.
• W2227501619 created "2016-06-24" @default.
• W2227501619 creator A5000232069 @default.
• W2227501619 creator A5001639700 @default.
• W2227501619 creator A5002524476 @default.
• W2227501619 creator A5003819366 @default.
• W2227501619 creator A5006299446 @default.
• W2227501619 creator A5014669606 @default.
• W2227501619 creator A5021984160 @default.
• W2227501619 creator A5028344690 @default.
• W2227501619 creator A5034787628 @default.
• W2227501619 creator A5056802642 @default.
• W2227501619 creator A5060653670 @default.
• W2227501619 creator A5063647348 @default.
• W2227501619 creator A5070268967 @default.
• W2227501619 date "2016-06-15" @default.
• W2227501619 modified "2023-09-27" @default.
• W2227501619 title "Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies" @default.
• W2227501619 cites W1600871539 @default.
• W2227501619 cites W1984075167 @default.
• W2227501619 cites W2001010258 @default.
• W2227501619 cites W2003251689 @default.
• W2227501619 cites W2020584298 @default.
• W2227501619 cites W2029863675 @default.
• W2227501619 cites W2031873458 @default.
• W2227501619 cites W2036083643 @default.
• W2227501619 cites W2038993099 @default.
• W2227501619 cites W2049069390 @default.
• W2227501619 cites W2051724020 @default.
• W2227501619 cites W2057248528 @default.
• W2227501619 cites W2061451815 @default.
• W2227501619 cites W2069694061 @default.
• W2227501619 cites W2082818184 @default.
• W2227501619 cites W2086021047 @default.
• W2227501619 cites W2093151091 @default.
• W2227501619 cites W2106178993 @default.
• W2227501619 cites W2110258679 @default.
• W2227501619 cites W2112295221 @default.
• W2227501619 cites W2114083062 @default.
• W2227501619 cites W2117202319 @default.
• W2227501619 cites W2117953016 @default.
• W2227501619 cites W2123677325 @default.
• W2227501619 cites W2131958728 @default.
• W2227501619 cites W2134508367 @default.
• W2227501619 cites W2150336758 @default.
• W2227501619 cites W2153822737 @default.
• W2227501619 cites W2155768516 @default.
• W2227501619 cites W2156012035 @default.
• W2227501619 cites W2157313480 @default.
• W2227501619 cites W2157461791 @default.
• W2227501619 cites W2159093158 @default.
• W2227501619 cites W2160641111 @default.
• W2227501619 cites W2165913798 @default.
• W2227501619 cites W2316529708 @default.
• W2227501619 cites W2432251212 @default.
• W2227501619 cites W3021292189 @default.
• W2227501619 cites W4245492581 @default.
• W2227501619 doi "https://doi.org/10.1164/rccm.201508-1602oc" @default.
• W2227501619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4910890" @default.
• W2227501619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26741046" @default.
• W2227501619 hasPublicationYear "2016" @default.
• W2227501619 type Work @default.
• W2227501619 sameAs 2227501619 @default.
• W2227501619 citedByCount "92" @default.
• W2227501619 countsByYear W22275016192016 @default.
• W2227501619 countsByYear W22275016192017 @default.
• W2227501619 countsByYear W22275016192018 @default.
• W2227501619 countsByYear W22275016192019 @default.
• W2227501619 countsByYear W22275016192020 @default.
• W2227501619 countsByYear W22275016192021 @default.
• W2227501619 countsByYear W22275016192022 @default.
• W2227501619 countsByYear W22275016192023 @default.
• W2227501619 crossrefType "journal-article" @default.
• W2227501619 hasAuthorship W2227501619A5000232069 @default.
• W2227501619 hasAuthorship W2227501619A5001639700 @default.
• W2227501619 hasAuthorship W2227501619A5002524476 @default.
• W2227501619 hasAuthorship W2227501619A5003819366 @default.
• W2227501619 hasAuthorship W2227501619A5006299446 @default.
• W2227501619 hasAuthorship W2227501619A5014669606 @default.
• W2227501619 hasAuthorship W2227501619A5021984160 @default.
• W2227501619 hasAuthorship W2227501619A5028344690 @default.
• W2227501619 hasAuthorship W2227501619A5034787628 @default.
• W2227501619 hasAuthorship W2227501619A5056802642 @default.
• W2227501619 hasAuthorship W2227501619A5060653670 @default.
• W2227501619 hasAuthorship W2227501619A5063647348 @default.
• W2227501619 hasAuthorship W2227501619A5070268967 @default.
• W2227501619 hasBestOaLocation W22275016192 @default.
• W2227501619 hasConcept C105922876 @default.
• W2227501619 hasConcept C126322002 @default.
• W2227501619 hasConcept C142724271 @default.
• W2227501619 hasConcept C170493617 @default.
• W2227501619 hasConcept C203014093 @default.
• W2227501619 hasConcept C24998067 @default.
• W2227501619 hasConcept C2776042228 @default.
• W2227501619 hasConcept C2776780178 @default.
• W2227501619 hasConcept C2777707825 @default.
• W2227501619 hasConcept C2777714996 @default.
• W2227501619 hasConcept C2780051329 @default.

• next