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- W2227503572 abstract "Candida glabrata has emerged as the second most prevalent fungal pathogenand its ability to form biofilms has been considered one of the most important virulencefactors, since biofilms present a high tolerance to antifungal agents used in fungalinfection treatment. The mechanisms of biofilm tolerance to antifungal agents remainpoorly understood. Thus, the aim of this study was to evaluate the effects of fluconazole(FLU) in the formation and control of C. glabrata biofilms, its relation with theexpression of genes encoding for ABC transporters, CDR1, SNQ2, and PDR1 and howthe ergosterol biosynthesis may be affected.Additionally to the high amounts of proteins and carbohydrates detected in theextracellular matrices in the presence of FLU, this work showed that the overexpressionof efflux pumps is a possible mechanism of biofilm tolerance to FLU and thisphenomenon alters the structure of C. glabrata biofilms by creating cell clusters." @default.
- W2227503572 created "2016-06-24" @default.
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- W2227503572 date "2013-01-01" @default.
- W2227503572 modified "2023-09-24" @default.
- W2227503572 title "Resistance mechanisms of Candida glabrata biofilmes to fluconazole" @default.
- W2227503572 hasPublicationYear "2013" @default.
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