FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227532016> ?p ?o ?g. }

• W2227532016 endingPage "600" @default.
• W2227532016 startingPage "595" @default.
• W2227532016 abstract "Objective　To observe the promotion effect of bone mesenchymal stem cells (BMSCs) transplantation and mobilized bone marrow stem cells on the recovery of liver function and liver tissue regeneration after massive partial hepatectomy in rats. Methods　The rats were randomly divided into four groups after massive partial hepatectomy (about 85%), namely massive hepatectomy group (control group, n=15, received massive hepatectomy only), G-CSF group [n=15, received rhG-CSF 150μg/(kg•d) by intraperitoneal injection after the operation for 5 days], MSCs group [n=15, received 5ml suspension of MSCs (about 1.5×106) by tail vein injection after the operation], and G-CSF+MSCs group [n=14, received 1.5ml suspension of MSCs (about 1.5×106) by tail vein injection and rhG-CSF 150μg/(kg•d) by intraperitoneal injection for 5 days after the operation]. The CD34+ cells in the peripheral blood of the rats were assessed by flow cytometry after G-CSF mobilization. Liver function tests including ALT, AST and ALB were performed on the 3rd and 9th day after surgery. All the rats were sacrificed and liver tissue was harvested for histopathological study. The expression of Ki-67 and BrdU positive cells in the liver were determined by immunohistochemistry. Results　Flow cytometric results identified the isolated cells were MSCs. BMSCs in peripheral blood significantly increased in number after rhG-CSF mobilization, and reaching the maximum number on the 5th day. After mobilization for 3, 5 and 9 days, the positive CD34 cells in G-CSF group were 0.009%, 0.016%, 0.019% respectively, which were higher than those in control group. The level of albumin was significantly elevated in three treatment groups compared with control group on the 9th day after the hepatectomy (P<0.05 or P<0.01). The expression of Ki-67 (110.16±27.64, 103.57±33.90, 98.52±21.87 vs 72.39±27.04 cells) and BrdU positive cells (17.96±5.57, 16.45±5.75, 16.66±5.11 vs 11.72±3.83 cells) in three treatment groups were higher than those in control group, with a statistically significant difference (P<0.01). Conclusion　Mobilization of hematopoietic stem cells by G-CSF or transplantation of allogenic BMSCs can promote the recovery of liver function and liver tissue regeneration, but their combination fails to show a synergistic effect.DOI: 10.11855/j.issn.0577-7402.2014.08.01" @default.
• W2227532016 created "2016-06-24" @default.
• W2227532016 creator A5003816728 @default.
• W2227532016 creator A5009232540 @default.
• W2227532016 creator A5035421259 @default.
• W2227532016 creator A5046667606 @default.
• W2227532016 creator A5056328923 @default.
• W2227532016 creator A5070544749 @default.
• W2227532016 creator A5078709272 @default.
• W2227532016 date "2014-08-01" @default.
• W2227532016 modified "2023-09-23" @default.
• W2227532016 title "A comparison of effects of bone marrow stem cell mobilization and bone marrow mesenchymal stem cell transplantation on the recovery of function and regeneration of rat liver tissue aftermassive excision of liver" @default.
• W2227532016 hasPublicationYear "2014" @default.
• W2227532016 type Work @default.
• W2227532016 sameAs 2227532016 @default.
• W2227532016 citedByCount "0" @default.
• W2227532016 crossrefType "journal-article" @default.
• W2227532016 hasAuthorship W2227532016A5003816728 @default.
• W2227532016 hasAuthorship W2227532016A5009232540 @default.
• W2227532016 hasAuthorship W2227532016A5035421259 @default.
• W2227532016 hasAuthorship W2227532016A5046667606 @default.
• W2227532016 hasAuthorship W2227532016A5056328923 @default.
• W2227532016 hasAuthorship W2227532016A5070544749 @default.
• W2227532016 hasAuthorship W2227532016A5078709272 @default.
• W2227532016 hasConcept C10205521 @default.
• W2227532016 hasConcept C126322002 @default.
• W2227532016 hasConcept C141071460 @default.
• W2227532016 hasConcept C142724271 @default.
• W2227532016 hasConcept C159110652 @default.
• W2227532016 hasConcept C16685009 @default.
• W2227532016 hasConcept C171056886 @default.
• W2227532016 hasConcept C198826908 @default.
• W2227532016 hasConcept C2776795407 @default.
• W2227532016 hasConcept C2776909242 @default.
• W2227532016 hasConcept C2780007613 @default.
• W2227532016 hasConcept C2780159080 @default.
• W2227532016 hasConcept C28328180 @default.
• W2227532016 hasConcept C2911091166 @default.
• W2227532016 hasConcept C2992208098 @default.
• W2227532016 hasConcept C54355233 @default.
• W2227532016 hasConcept C71924100 @default.
• W2227532016 hasConcept C86803240 @default.
• W2227532016 hasConcept C95444343 @default.
• W2227532016 hasConceptScore W2227532016C10205521 @default.
• W2227532016 hasConceptScore W2227532016C126322002 @default.
• W2227532016 hasConceptScore W2227532016C141071460 @default.
• W2227532016 hasConceptScore W2227532016C142724271 @default.
• W2227532016 hasConceptScore W2227532016C159110652 @default.
• W2227532016 hasConceptScore W2227532016C16685009 @default.
• W2227532016 hasConceptScore W2227532016C171056886 @default.
• W2227532016 hasConceptScore W2227532016C198826908 @default.
• W2227532016 hasConceptScore W2227532016C2776795407 @default.
• W2227532016 hasConceptScore W2227532016C2776909242 @default.
• W2227532016 hasConceptScore W2227532016C2780007613 @default.
• W2227532016 hasConceptScore W2227532016C2780159080 @default.
• W2227532016 hasConceptScore W2227532016C28328180 @default.
• W2227532016 hasConceptScore W2227532016C2911091166 @default.
• W2227532016 hasConceptScore W2227532016C2992208098 @default.
• W2227532016 hasConceptScore W2227532016C54355233 @default.
• W2227532016 hasConceptScore W2227532016C71924100 @default.
• W2227532016 hasConceptScore W2227532016C86803240 @default.
• W2227532016 hasConceptScore W2227532016C95444343 @default.
• W2227532016 hasIssue "8" @default.
• W2227532016 hasLocation W22275320161 @default.
• W2227532016 hasOpenAccess W2227532016 @default.
• W2227532016 hasPrimaryLocation W22275320161 @default.
• W2227532016 hasRelatedWork W1842800599 @default.
• W2227532016 hasRelatedWork W2046867884 @default.
• W2227532016 hasRelatedWork W2351217795 @default.
• W2227532016 hasRelatedWork W2352724558 @default.
• W2227532016 hasRelatedWork W2354265349 @default.
• W2227532016 hasRelatedWork W2359407680 @default.
• W2227532016 hasRelatedWork W2360985027 @default.
• W2227532016 hasRelatedWork W2377122159 @default.
• W2227532016 hasRelatedWork W2377779116 @default.
• W2227532016 hasRelatedWork W2378857470 @default.
• W2227532016 hasRelatedWork W2380205864 @default.
• W2227532016 hasRelatedWork W2380706610 @default.
• W2227532016 hasRelatedWork W2386280098 @default.
• W2227532016 hasRelatedWork W2386361973 @default.
• W2227532016 hasRelatedWork W2745205844 @default.
• W2227532016 hasRelatedWork W3028740533 @default.
• W2227532016 hasRelatedWork W3029146564 @default.
• W2227532016 hasRelatedWork W3030204336 @default.
• W2227532016 hasRelatedWork W3030493504 @default.
• W2227532016 hasRelatedWork W3031477978 @default.
• W2227532016 hasVolume "39" @default.
• W2227532016 isParatext "false" @default.
• W2227532016 isRetracted "false" @default.
• W2227532016 magId "2227532016" @default.
• W2227532016 workType "article" @default.