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• W2227578741 abstract "Genomic imprinting is a critical developmental process characteristic of parent of origin-specific gene expression. It is well accepted that differentially DNA-methylated regions (DMRs) and enhancers are two major classes of cis-elements determining parent of origin-specific gene expression, with each recruiting different sets of transcription factors. Previously, we identified the AF4/FMR2 (AFF) family protein AFF3 within the transcription elongation complex SEC-L3. Here, we report that AFF3 can specifically bind both gametic DMRs (gDMRs) and enhancers within imprinted loci in an allele-specific manner. We identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an ∼200-kb polycistronic transcript within the imprinted Dlk1-Dio3 locus. Our data suggest that the heterochromatic environment at the gDMR reinforces silencing of its related enhancer by controlling the binding and activity of AFF3 in an allele-specific manner. In summary, this study provides molecular details about the regulation of dosage-critical imprinted gene expression through the regulated binding of the transcription elongation factor AFF3 between a DMR and an enhancer." @default.
• W2227578741 created "2016-06-24" @default.
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• W2227578741 date "2016-01-01" @default.
• W2227578741 modified "2023-10-12" @default.
• W2227578741 title "Regulation of the imprinted <i>Dlk1-Dio3</i> locus by allele-specific enhancer activity" @default.
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• W2227578741 doi "https://doi.org/10.1101/gad.270413.115" @default.
• W2227578741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4701981" @default.
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• W2227578741 hasPublicationYear "2016" @default.
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