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- W222759769 abstract "The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized candidatebreast and lung cancer gene. The gene contains a DMAP1 binding domain, pointing topotential involvement in DNMT1-dependent methylation. To study the role of DIP2C intumor development, we engineered human DIP2C knockout cell systems by rAAV-mediatedgene targeting. Homo- and heterozygous RKO DIP2C knockout cells displayed enlarged cellsand growth retardation. This phenotype was most pronounced in DIP2C-/- knockouts, andthese cells also displayed a significant decrease in DIP2C mRNA levels. RNA sequencingrevealed 780 genes affected by the loss of DIP2C, including the cellular senescence markerP16INK4a. Functional annotation of the regulated genes shows enrichment of genes involvedwith cell death processes, cell structure and motility. Furthermore, KEGG pathway analysisshows association of 19 genes with pathways in cancer. In conclusion, the phenotypic dataand expression changes induced by loss of DIP2C indicate that the gene function may beimportant for several biological processes implicated in cancer, and that loss of gene functionmay be a trigger of cellular senescence." @default.
- W222759769 created "2016-06-24" @default.
- W222759769 creator A5042386888 @default.
- W222759769 date "2014-01-01" @default.
- W222759769 modified "2023-09-23" @default.
- W222759769 title "Understanding Cancer Mutations by Genome Editing" @default.
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