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• W2227653819 endingPage "311" @default.
• W2227653819 startingPage "301" @default.
• W2227653819 abstract "The attachment of dissimilar materials is a major engineering challenge, yet this challenge is seemingly overcome in biology. This study aimed to determine how the transcription factor Scleraxis (Scx) influences the development and maturation of the tendon-to-bone attachment (enthesis). Mice with conditional knockout (cKO) for Scx (Scx(flx/-), Prx1Cre(+)) and wild-type [(WT) Scx(flx/+) or Scx(flx/flx)] littermates were killed at postnatal days 7-56 (P7-P56). Enthesis morphometry, histology, and collagen alignment were investigated throughout postnatal growth. Enthesis tensile mechanical properties were also assessed. Laser microdissection of distinct musculoskeletal tissues was performed at P7 for WT, cKO, and muscle-unloaded (botulinum toxin A treated) attachments for quantitative PCR. cKO mice were smaller, with altered bone shape and impaired enthesis morphology, morphometry, and organization. Structural alterations led to altered mechanical properties; cKO entheses demonstrated reduced strength and stiffness. In P7 attachments, cKO mice had reduced expression of transforming growth factor (TGF) superfamily genes in fibrocartilage compared with WT mice. In conclusion, deletion of Scx led to impairments in enthesis structure, which translated into impaired functional (i.e., mechanical) outcomes. These changes may be driven by transient signaling cues from mechanical loading and growth factors." @default.
• W2227653819 created "2016-06-24" @default.
• W2227653819 creator A5009924286 @default.
• W2227653819 creator A5017760564 @default.
• W2227653819 date "2015-10-06" @default.
• W2227653819 modified "2023-10-17" @default.
• W2227653819 title "Scleraxis is required for the development of a functional tendon enthesis" @default.
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• W2227653819 doi "https://doi.org/10.1096/fj.14-258236" @default.
• W2227653819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4684511" @default.
• W2227653819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26443819" @default.
• W2227653819 hasPublicationYear "2015" @default.
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