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• W2227657047 startingPage "117" @default.
• W2227657047 abstract "Cellular rejection of a cardiac allograft is mediated by T-lymphocytes. To study the function of these T cells, graft infiltrating T-lymphocytes propagated from endomyocardial biopsies were analyzed for their capacity to lyse donor derived target cells. Subsequently, the structure of T cell receptor V-regions was analyzed to determine the nature of the cardiac alloresponses. Our studies have revealed that donor-specific cytotoxic T cell lines can be established from endomyocardinfiltrating T-lymphocytes. T cell clones established from these donor-specific T cell lines displayed multiple specificities against donor encoded cell surface antigens. Some of these allo specific T cell clones expressed identical T cell receptors, revealing that they were derived from the same progenitor. T cell clones specific for different donor allo-antigens expressed multiple TCRAV and TCRBV regions. Also, T cell clones, reactive against the same donor allo-antigens, but established from sequentially taken biopsies from the same patient displayed a different TCRAV and TCRBV repertoire. Taken together, our studies suggest that within a given patient the allo-specific T cell repertoire of T cells which have accumulated into the cardiac allograft is compressed." @default.
• W2227657047 created "2016-06-24" @default.
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• W2227657047 date "1995-01-01" @default.
• W2227657047 modified "2023-10-17" @default.
• W2227657047 title "Structure of T Cell Receptor Vα and Vβ Chains Expressed by T-Lymphocytes in Cardiac Allograft Derived Cell Lines" @default.
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• W2227657047 doi "https://doi.org/10.1007/978-3-662-22494-6_6" @default.
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