Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227672221> ?p ?o ?g. }
- W2227672221 abstract "Antigens (Ags) expressed by cancer cells can be specifically recognised by T cells contributing to anti-tumour immunity. For this reason, tumour Ag-specific T helper type 1 (Th1) cells can be detected in cancers and their infiltration is predictive of a prolonged disease-free survival. However, their activity is suppressed by T cells with inhibitory functions i.e. regulatory T cells (Tregs). High infiltration of tumours by these cells often correlates with poor survival. It is therefore crucial to understand their activity. Since Th1 and Treg cells are activated after Ag recognition, it is plausible that tumour Ag-specific Tregs inhibit Th1-mediated tumour immunity. Furthermore, vaccination, rather than inducing effector T cells, may be detrimental by activating Tregs.Increased numbers of CD25hi Treg cells are found in cancer patients, including CRC. However, in contrast to many cancers, the phenotype of these cells has not been studied in CRC patients. In this thesis, phenotypes of circulating, colon and tumour infiltrating Tregs are described. A high percentage of intratumoural CD4+CD25hi Tregs was found to express immunosuppressive molecules and these cells were enriched in late-stage CRC tumours. In addition, this thesis describes the measurement of Th1 and Treg cells recognising the oncofetal Ag, 5T4. Four immunogenic regions within the oncofoetal tumour Ag 5T4 and 14 peptides able to bind to most commonly found human HLA-DR alleles were identified. CD4+CD25hi cells mediated the control of tumour Ag 5T4-specific Th1 responses in CRC patients and their suppressive activity was not restricted to Th1 cells of the same Ag specificity. Also, responses to some, but importantly not all, immunogenic helper peptides discovered were influenced by Tregs. Thus Tregs may contribute to CRC progression by influencing tumour Ag- specific responses of Th1 cells.This body of work brings more information regarding the tumour Ag-specificity of Tregs and offers a future rationale to design peptide-based vaccines which exclude Treg peptides." @default.
- W2227672221 created "2016-06-24" @default.
- W2227672221 creator A5051279530 @default.
- W2227672221 date "2015-01-01" @default.
- W2227672221 modified "2023-09-24" @default.
- W2227672221 title "Elucidating the role of regulatory T cells in colorectal cancer progression" @default.
- W2227672221 cites W1483194800 @default.
- W2227672221 cites W1493822493 @default.
- W2227672221 cites W1494102420 @default.
- W2227672221 cites W1501042206 @default.
- W2227672221 cites W1503997891 @default.
- W2227672221 cites W1504508343 @default.
- W2227672221 cites W1529036199 @default.
- W2227672221 cites W1530782041 @default.
- W2227672221 cites W1537214946 @default.
- W2227672221 cites W1556459637 @default.
- W2227672221 cites W1560277370 @default.
- W2227672221 cites W1567420244 @default.
- W2227672221 cites W1573470869 @default.
- W2227672221 cites W1575585006 @default.
- W2227672221 cites W1588272261 @default.
- W2227672221 cites W1599507531 @default.
- W2227672221 cites W1601925808 @default.
- W2227672221 cites W1626388077 @default.
- W2227672221 cites W1642873092 @default.
- W2227672221 cites W1647115901 @default.
- W2227672221 cites W1661441964 @default.
- W2227672221 cites W1671127425 @default.
- W2227672221 cites W1675195038 @default.
- W2227672221 cites W1678167583 @default.
- W2227672221 cites W1680217275 @default.
- W2227672221 cites W1692686725 @default.
- W2227672221 cites W1835750525 @default.
- W2227672221 cites W187920822 @default.
- W2227672221 cites W1894110757 @default.
- W2227672221 cites W1922646908 @default.
- W2227672221 cites W1934905808 @default.
- W2227672221 cites W1941651450 @default.
- W2227672221 cites W1944833403 @default.
- W2227672221 cites W1958745508 @default.
- W2227672221 cites W1963673812 @default.
- W2227672221 cites W1963939177 @default.
- W2227672221 cites W1964052073 @default.
- W2227672221 cites W1964612175 @default.
- W2227672221 cites W1965289329 @default.
- W2227672221 cites W1965734808 @default.
- W2227672221 cites W1966768211 @default.
- W2227672221 cites W1967261754 @default.
- W2227672221 cites W1968716725 @default.
- W2227672221 cites W1970589909 @default.
- W2227672221 cites W1971085650 @default.
- W2227672221 cites W1972451040 @default.
- W2227672221 cites W1972826411 @default.
- W2227672221 cites W1973599173 @default.
- W2227672221 cites W1973888069 @default.
- W2227672221 cites W1974147521 @default.
- W2227672221 cites W1974377674 @default.
- W2227672221 cites W1975588465 @default.
- W2227672221 cites W1977912132 @default.
- W2227672221 cites W1978020435 @default.
- W2227672221 cites W1979391629 @default.
- W2227672221 cites W1979657237 @default.
- W2227672221 cites W1980621729 @default.
- W2227672221 cites W1981032637 @default.
- W2227672221 cites W1981417548 @default.
- W2227672221 cites W1981480494 @default.
- W2227672221 cites W1982926364 @default.
- W2227672221 cites W1983356813 @default.
- W2227672221 cites W1983461786 @default.
- W2227672221 cites W1983812780 @default.
- W2227672221 cites W1984909066 @default.
- W2227672221 cites W1987246352 @default.
- W2227672221 cites W1987375206 @default.
- W2227672221 cites W1987735044 @default.
- W2227672221 cites W1988474688 @default.
- W2227672221 cites W1990295999 @default.
- W2227672221 cites W1990797005 @default.
- W2227672221 cites W1991344211 @default.
- W2227672221 cites W1991524518 @default.
- W2227672221 cites W1992196706 @default.
- W2227672221 cites W1992249154 @default.
- W2227672221 cites W1992743812 @default.
- W2227672221 cites W1994160001 @default.
- W2227672221 cites W1995570137 @default.
- W2227672221 cites W1996445917 @default.
- W2227672221 cites W1997317519 @default.
- W2227672221 cites W1997491414 @default.
- W2227672221 cites W1997493715 @default.
- W2227672221 cites W1998350666 @default.
- W2227672221 cites W1998603634 @default.
- W2227672221 cites W1999227421 @default.
- W2227672221 cites W1999554027 @default.
- W2227672221 cites W1999601075 @default.
- W2227672221 cites W2000941161 @default.
- W2227672221 cites W2001716606 @default.
- W2227672221 cites W2001744598 @default.
- W2227672221 cites W2003842888 @default.
- W2227672221 cites W2004007622 @default.
- W2227672221 cites W2004282938 @default.
- W2227672221 cites W2005154465 @default.