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• W2227807225 startingPage "125" @default.
• W2227807225 abstract "Abstract In an attempt to monitor μ m ‐level trace constituents, we applied here 1 H‐{ 13 C‐ 15 N} triple‐resonance nuclear magnetic resonance (NMR) to 13 C/ 15 N‐enriched l ‐Dopa as the inevitable precursor of the neurotransmitter dopamine in the brain. The perfect selectivity (to render endogenous components silent) and μ m ‐level sensitivity (700 MHz spectrometer equipped with a cryogenic probe) of triple‐resonance allowed the unambiguous and quantitative metabolic and pharmacokinetic analyses of administered l ‐Dopa/dopamine in the brain and liver of mice. The level of dopamine generated in the brain (within the range 7–76 μ m , which covers the typical stimulated level of ∼30 μ m ) could be clearly monitored ex vivo, but was slightly short of the detection limit of a 7 T MR machine for small animals. This work suggests that μ m ‐level trace constituents are potential targets of ex vivo monitoring as long as they contain N atom(s) and their appropriate 13 C/ 15 N‐enrichment is synthetically accessible." @default.
• W2227807225 created "2016-06-24" @default.
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• W2227807225 date "2015-12-30" @default.
• W2227807225 modified "2023-10-16" @default.
• W2227807225 title "¹³C/¹⁵N‐Enriched <scp>l</scp>‐Dopa as a Triple‐Resonance NMR Probe to Monitor Neurotransmitter Dopamine in the Brain and Liver Extracts of Mice" @default.
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• W2227807225 doi "https://doi.org/10.1002/open.201500196" @default.
• W2227807225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4906467" @default.
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