Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227831768> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2227831768 endingPage "21" @default.
- W2227831768 startingPage "715" @default.
- W2227831768 abstract "AlCl3 or GaCl3 was added to artificial cerebrospinal fluid and perfused through the cerebral ventricles of the rat. Depending on the metal and its concentration (1-10 mM) the pH of the perfusate ranged from 7.2 to 3.5. At 10 mM metal chloride, yielding pH 4.7 (Al) or 3.5 (Ga), formation of cerebrospinal fluid was suppressed 100%. The effect was reversed as soon as control cerebrospinal fluid (pH 7.35) was introduced. There was no effect at pH greater than 6 in the presence of metal ions nor was the effect mimicked by cerebrospinal fluid acidified with HCl or phosphate buffer to pH 4.7. HCl and phosphate at pH 4.7 had partial effects (25-30%). Inhibition of carbonic anhydrase is well known to have a partial effect (approximately 50%), the remainder of normal flow being dependent on the uncatalyzed formation of HCO3- and the corresponding movement of Na+. The complete cessation of flow after exposure to Al or Ga ions appears to occur when these ions are perfused at pH where they are partly hydrolyzed. Under these circumstances they form very powerful proton generating systems (as shown by titration data), which could lower [OH-] at the secretory border of choroid plexus cells. As a result, both the catalyzed and the uncatalyzed processes for formation of HCO3- from CO2 are abolished and secretion stops. This mechanism may also account for the antiperspirant action of Al salts. Using metal ion hydrolysis to probe other secretory systems will also be of interest." @default.
- W2227831768 created "2016-06-24" @default.
- W2227831768 creator A5025514143 @default.
- W2227831768 creator A5031187700 @default.
- W2227831768 creator A5035184706 @default.
- W2227831768 date "1985-06-01" @default.
- W2227831768 modified "2023-09-23" @default.
- W2227831768 title "Aluminum and gallium arrest formation of cerebrospinal fluid by the mechanism of OH- depletion." @default.
- W2227831768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2989493" @default.
- W2227831768 hasPublicationYear "1985" @default.
- W2227831768 type Work @default.
- W2227831768 sameAs 2227831768 @default.
- W2227831768 citedByCount "2" @default.
- W2227831768 crossrefType "journal-article" @default.
- W2227831768 hasAuthorship W2227831768A5025514143 @default.
- W2227831768 hasAuthorship W2227831768A5031187700 @default.
- W2227831768 hasAuthorship W2227831768A5035184706 @default.
- W2227831768 hasConcept C12554922 @default.
- W2227831768 hasConcept C126322002 @default.
- W2227831768 hasConcept C178790620 @default.
- W2227831768 hasConcept C179104552 @default.
- W2227831768 hasConcept C181199279 @default.
- W2227831768 hasConcept C184866935 @default.
- W2227831768 hasConcept C185592680 @default.
- W2227831768 hasConcept C199164860 @default.
- W2227831768 hasConcept C2775914622 @default.
- W2227831768 hasConcept C2776538271 @default.
- W2227831768 hasConcept C2777132085 @default.
- W2227831768 hasConcept C2778695967 @default.
- W2227831768 hasConcept C2779651940 @default.
- W2227831768 hasConcept C43617362 @default.
- W2227831768 hasConcept C529278444 @default.
- W2227831768 hasConcept C544153396 @default.
- W2227831768 hasConcept C55493867 @default.
- W2227831768 hasConcept C71924100 @default.
- W2227831768 hasConcept C86803240 @default.
- W2227831768 hasConcept C94412978 @default.
- W2227831768 hasConceptScore W2227831768C12554922 @default.
- W2227831768 hasConceptScore W2227831768C126322002 @default.
- W2227831768 hasConceptScore W2227831768C178790620 @default.
- W2227831768 hasConceptScore W2227831768C179104552 @default.
- W2227831768 hasConceptScore W2227831768C181199279 @default.
- W2227831768 hasConceptScore W2227831768C184866935 @default.
- W2227831768 hasConceptScore W2227831768C185592680 @default.
- W2227831768 hasConceptScore W2227831768C199164860 @default.
- W2227831768 hasConceptScore W2227831768C2775914622 @default.
- W2227831768 hasConceptScore W2227831768C2776538271 @default.
- W2227831768 hasConceptScore W2227831768C2777132085 @default.
- W2227831768 hasConceptScore W2227831768C2778695967 @default.
- W2227831768 hasConceptScore W2227831768C2779651940 @default.
- W2227831768 hasConceptScore W2227831768C43617362 @default.
- W2227831768 hasConceptScore W2227831768C529278444 @default.
- W2227831768 hasConceptScore W2227831768C544153396 @default.
- W2227831768 hasConceptScore W2227831768C55493867 @default.
- W2227831768 hasConceptScore W2227831768C71924100 @default.
- W2227831768 hasConceptScore W2227831768C86803240 @default.
- W2227831768 hasConceptScore W2227831768C94412978 @default.
- W2227831768 hasIssue "3" @default.
- W2227831768 hasLocation W22278317681 @default.
- W2227831768 hasOpenAccess W2227831768 @default.
- W2227831768 hasPrimaryLocation W22278317681 @default.
- W2227831768 hasRelatedWork W1997826252 @default.
- W2227831768 hasRelatedWork W2026706159 @default.
- W2227831768 hasRelatedWork W2036937356 @default.
- W2227831768 hasRelatedWork W2053224445 @default.
- W2227831768 hasRelatedWork W2071299881 @default.
- W2227831768 hasRelatedWork W2085049824 @default.
- W2227831768 hasRelatedWork W2090472350 @default.
- W2227831768 hasRelatedWork W2258833546 @default.
- W2227831768 hasRelatedWork W2348545518 @default.
- W2227831768 hasRelatedWork W2950717927 @default.
- W2227831768 hasVolume "233" @default.
- W2227831768 isParatext "false" @default.
- W2227831768 isRetracted "false" @default.
- W2227831768 magId "2227831768" @default.
- W2227831768 workType "article" @default.