Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227904090> ?p ?o ?g. }
- W2227904090 abstract "The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor HoxA9, forms nuclear aggregates that frequently associate with facultative heterochromatin. We demonstrate that stable expression of Nup98-HoxA9 in mouse embryonic stem cells selectively induces the expression of Hox cluster genes. Genome-wide binding site analysis revealed that Nup98-HoxA9 is preferentially targeted and accumulated at Hox cluster regions where the export factor Crm1 is originally prebound. In addition, leptomycin B, an inhibitor of Crm1, disassembled nuclear Nup98-HoxA9 dots, resulting in the loss of chromatin binding of Nup98-HoxA9 and Nup98-HoxA9-mediated activation of Hox genes. Collectively, our results indicate that highly selective targeting of Nup98-fusion proteins to Hox cluster regions via prebound Crm1 induces the formation of higher order chromatin structures that causes aberrant Hox gene regulation." @default.
- W2227904090 created "2016-06-24" @default.
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- W2227904090 creator A5084921992 @default.
- W2227904090 date "2016-01-07" @default.
- W2227904090 modified "2023-10-06" @default.
- W2227904090 title "Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes" @default.
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- W2227904090 cites W1968975193 @default.
- W2227904090 cites W1972583137 @default.
- W2227904090 cites W1972769296 @default.
- W2227904090 cites W1973642076 @default.
- W2227904090 cites W1992314522 @default.
- W2227904090 cites W1996313023 @default.
- W2227904090 cites W1997124230 @default.
- W2227904090 cites W1998223106 @default.
- W2227904090 cites W1999389174 @default.
- W2227904090 cites W2001542610 @default.
- W2227904090 cites W2003706637 @default.
- W2227904090 cites W2005412609 @default.
- W2227904090 cites W2007755820 @default.
- W2227904090 cites W2011108752 @default.
- W2227904090 cites W2017840637 @default.
- W2227904090 cites W2018051857 @default.
- W2227904090 cites W2024387549 @default.
- W2227904090 cites W2027337958 @default.
- W2227904090 cites W2029733458 @default.
- W2227904090 cites W2033887186 @default.
- W2227904090 cites W2038019363 @default.
- W2227904090 cites W2042633640 @default.
- W2227904090 cites W2043455507 @default.
- W2227904090 cites W2044016151 @default.
- W2227904090 cites W2047724766 @default.
- W2227904090 cites W2048865995 @default.
- W2227904090 cites W2049556442 @default.
- W2227904090 cites W2049598074 @default.
- W2227904090 cites W2049625449 @default.
- W2227904090 cites W2052009094 @default.
- W2227904090 cites W2054555589 @default.
- W2227904090 cites W2055730957 @default.
- W2227904090 cites W2059952299 @default.
- W2227904090 cites W2060136033 @default.
- W2227904090 cites W2067563155 @default.
- W2227904090 cites W2068336761 @default.
- W2227904090 cites W2068363360 @default.
- W2227904090 cites W2069409792 @default.
- W2227904090 cites W2070476377 @default.
- W2227904090 cites W2072035127 @default.
- W2227904090 cites W2072274637 @default.
- W2227904090 cites W2075327666 @default.
- W2227904090 cites W2080896401 @default.
- W2227904090 cites W2086598626 @default.
- W2227904090 cites W2092015664 @default.
- W2227904090 cites W2096857560 @default.
- W2227904090 cites W2098020712 @default.
- W2227904090 cites W2098686783 @default.
- W2227904090 cites W2100747051 @default.
- W2227904090 cites W2101689648 @default.
- W2227904090 cites W2103535655 @default.
- W2227904090 cites W2104364444 @default.
- W2227904090 cites W2106666487 @default.
- W2227904090 cites W2108130094 @default.
- W2227904090 cites W2114875490 @default.
- W2227904090 cites W2129446623 @default.
- W2227904090 cites W2129821375 @default.
- W2227904090 cites W2131322090 @default.
- W2227904090 cites W2131878394 @default.
- W2227904090 cites W2137574966 @default.
- W2227904090 cites W2140117392 @default.
- W2227904090 cites W2140907670 @default.
- W2227904090 cites W2146614388 @default.
- W2227904090 cites W2156510716 @default.
- W2227904090 cites W2157989184 @default.
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- W2227904090 doi "https://doi.org/10.7554/elife.09540" @default.
- W2227904090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4718815" @default.
- W2227904090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26740045" @default.
- W2227904090 hasPublicationYear "2016" @default.
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