Matches in SemOpenAlex for { <https://semopenalex.org/work/W2227937531> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2227937531 endingPage "1704" @default.
- W2227937531 startingPage "1704" @default.
- W2227937531 abstract "1704 Objectives Myocarditis, an inflammatory disease of the myocardium, is a major cause of death and dilated cardiomyopathy. However its work-up is not standardized due to the lack of reliable marker of progression. The disease is characterized by clusters of lymphoid and myeloid cell infiltrates, and endothelial activation which hallmark is the expression of adhesion molecules such as selectins. The aim of the study was to evaluate the ability of 99mTc-fucoidan, an imaging agent specific of selectins, in the assessment of inflammation in a model of experimental autoimmune myocarditis (EAM). Methods EAM has been induced in male Lewis rats with purified rat cardiomyosin and compared with controls. The experiments were performed in the very early phase of myocarditis (10, 15 and 21 days after immunization) and included (1) quantification of 99mTc-fucoidan myocardial/lung ratio using SPECT/CT; (2) qualitatively: comparative analysis on adjacent slices of tracer uptake on autoradiography and selectins on immuno-histochemistry (CD62p, CD62e); and (3) quantitatively: relationship between 99mTc-fucoidan uptake by well counting (expressed as %ID/g of myocardium) and myocardial content of inflammatory cells (CD45; CD11b) using flow cytometry. Results myocardial uptake of 99mTc-fucoidan was significantly increased in EAM compared to controls (SPECT uptake ratio: 1.6±0.1 vs. 1.2±0.4, p=0.04 at D10; 2.3±0.2 vs. 1.3±0.8, p Conclusions 99mTc-fucoidan allows detecting early steps of endothelial activation associated with EAM, and its uptake is correlated with myocardial content in inflammatory cells. Further study is required to determine whether it may allow monitoring chronic disease and/or therapy efficacy. Research Support T. Cognet was supported by a research grant from the French Federation of Cardiology" @default.
- W2227937531 created "2016-06-24" @default.
- W2227937531 creator A5001462379 @default.
- W2227937531 creator A5005677612 @default.
- W2227937531 creator A5010712276 @default.
- W2227937531 creator A5024002205 @default.
- W2227937531 creator A5035755522 @default.
- W2227937531 creator A5036984977 @default.
- W2227937531 creator A5042887533 @default.
- W2227937531 creator A5057191953 @default.
- W2227937531 creator A5063400748 @default.
- W2227937531 creator A5068422952 @default.
- W2227937531 date "2014-05-01" @default.
- W2227937531 modified "2023-09-24" @default.
- W2227937531 title "Detection of inflammation in experimental autoimmune myocarditis using 99mTc-fucoidan SPECT" @default.
- W2227937531 hasPublicationYear "2014" @default.
- W2227937531 type Work @default.
- W2227937531 sameAs 2227937531 @default.
- W2227937531 citedByCount "0" @default.
- W2227937531 crossrefType "journal-article" @default.
- W2227937531 hasAuthorship W2227937531A5001462379 @default.
- W2227937531 hasAuthorship W2227937531A5005677612 @default.
- W2227937531 hasAuthorship W2227937531A5010712276 @default.
- W2227937531 hasAuthorship W2227937531A5024002205 @default.
- W2227937531 hasAuthorship W2227937531A5035755522 @default.
- W2227937531 hasAuthorship W2227937531A5036984977 @default.
- W2227937531 hasAuthorship W2227937531A5042887533 @default.
- W2227937531 hasAuthorship W2227937531A5057191953 @default.
- W2227937531 hasAuthorship W2227937531A5063400748 @default.
- W2227937531 hasAuthorship W2227937531A5068422952 @default.
- W2227937531 hasConcept C100817775 @default.
- W2227937531 hasConcept C126322002 @default.
- W2227937531 hasConcept C142724271 @default.
- W2227937531 hasConcept C155619193 @default.
- W2227937531 hasConcept C185592680 @default.
- W2227937531 hasConcept C203014093 @default.
- W2227937531 hasConcept C2775909754 @default.
- W2227937531 hasConcept C2776914184 @default.
- W2227937531 hasConcept C2779902710 @default.
- W2227937531 hasConcept C2780875844 @default.
- W2227937531 hasConcept C553184892 @default.
- W2227937531 hasConcept C55493867 @default.
- W2227937531 hasConcept C71924100 @default.
- W2227937531 hasConceptScore W2227937531C100817775 @default.
- W2227937531 hasConceptScore W2227937531C126322002 @default.
- W2227937531 hasConceptScore W2227937531C142724271 @default.
- W2227937531 hasConceptScore W2227937531C155619193 @default.
- W2227937531 hasConceptScore W2227937531C185592680 @default.
- W2227937531 hasConceptScore W2227937531C203014093 @default.
- W2227937531 hasConceptScore W2227937531C2775909754 @default.
- W2227937531 hasConceptScore W2227937531C2776914184 @default.
- W2227937531 hasConceptScore W2227937531C2779902710 @default.
- W2227937531 hasConceptScore W2227937531C2780875844 @default.
- W2227937531 hasConceptScore W2227937531C553184892 @default.
- W2227937531 hasConceptScore W2227937531C55493867 @default.
- W2227937531 hasConceptScore W2227937531C71924100 @default.
- W2227937531 hasLocation W22279375311 @default.
- W2227937531 hasOpenAccess W2227937531 @default.
- W2227937531 hasPrimaryLocation W22279375311 @default.
- W2227937531 hasRelatedWork W1970441721 @default.
- W2227937531 hasRelatedWork W1998863382 @default.
- W2227937531 hasRelatedWork W2009693911 @default.
- W2227937531 hasRelatedWork W2019624622 @default.
- W2227937531 hasRelatedWork W2033988691 @default.
- W2227937531 hasRelatedWork W2034393732 @default.
- W2227937531 hasRelatedWork W2072451161 @default.
- W2227937531 hasRelatedWork W2119728827 @default.
- W2227937531 hasRelatedWork W2138524724 @default.
- W2227937531 hasRelatedWork W2354881646 @default.
- W2227937531 hasRelatedWork W2372169302 @default.
- W2227937531 hasRelatedWork W2372555043 @default.
- W2227937531 hasRelatedWork W2379019426 @default.
- W2227937531 hasRelatedWork W2380197312 @default.
- W2227937531 hasRelatedWork W2432654488 @default.
- W2227937531 hasRelatedWork W2508867100 @default.
- W2227937531 hasRelatedWork W2791937907 @default.
- W2227937531 hasRelatedWork W3010206605 @default.
- W2227937531 hasRelatedWork W3039884981 @default.
- W2227937531 hasRelatedWork W3174221970 @default.
- W2227937531 hasVolume "55" @default.
- W2227937531 isParatext "false" @default.
- W2227937531 isRetracted "false" @default.
- W2227937531 magId "2227937531" @default.
- W2227937531 workType "article" @default.