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- W2227994377 abstract "Abstract Posttraumatic stress disorder (PTSD) is a prevalent, debilitating, and difficult to treat psychiatric disorder. Very little is known of how PTSD affects neuroplasticity in the developing adolescent brain. Whereas multiple lines of research implicate amygdala‐centered network dysfunction in the pathophysiology of adult PTSD, no study has yet examined the functional architecture of amygdala subregional networks in adolescent PTSD. Using intrinsic functional connectivity analysis, we investigated functional connectivity of the basolateral (BLA) and centromedial (CMA) amygdala in 19 sexually abused adolescents with PTSD relative to 23 matched controls. Additionally, we examined whether altered amygdala subregional connectivity coincides with abnormal grey matter volume of the amygdaloid complex. Our analysis revealed abnormal amygdalar connectivity and morphology in adolescent PTSD patients. More specifically, PTSD patients showed diminished right BLA connectivity with a cluster including dorsal and ventral portions of the anterior cingulate and medial prefrontal cortices ( p < 0.05, corrected). In contrast, PTSD patients showed increased left CMA connectivity with a cluster including the orbitofrontal and subcallosal cortices ( p < 0.05, corrected). Critically, these connectivity changes coincided with diminished grey matter volume within BLA and CMA subnuclei ( p < 0.05, corrected), with CMA connectivity shifts additionally relating to more severe symptoms of PTSD. These findings provide unique insights into how perturbations in major amygdalar circuits could hamper fear regulation and drive excessive acquisition and expression of fear in PTSD. As such, they represent an important step toward characterizing the neurocircuitry of adolescent PTSD, thereby informing the development of reliable biomarkers and potential therapeutic targets. Hum Brain Mapp 37:1120–1135, 2016 . © 2016 Wiley Periodicals, Inc ." @default.
- W2227994377 created "2016-06-24" @default.
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- W2227994377 creator A5065914857 @default.
- W2227994377 date "2016-01-06" @default.
- W2227994377 modified "2023-10-01" @default.
- W2227994377 title "Abnormal functional architecture of amygdala‐centered networks in adolescent posttraumatic stress disorder" @default.
- W2227994377 cites W1604789895 @default.
- W2227994377 cites W1758209537 @default.
- W2227994377 cites W1964647061 @default.
- W2227994377 cites W1965642520 @default.
- W2227994377 cites W1965965542 @default.
- W2227994377 cites W1967024413 @default.
- W2227994377 cites W1968173341 @default.
- W2227994377 cites W1970695058 @default.
- W2227994377 cites W1970780234 @default.
- W2227994377 cites W1971662253 @default.
- W2227994377 cites W1976872417 @default.
- W2227994377 cites W1984489485 @default.
- W2227994377 cites W1987375729 @default.
- W2227994377 cites W1989045560 @default.
- W2227994377 cites W1990134753 @default.
- W2227994377 cites W1991817706 @default.
- W2227994377 cites W1993630149 @default.
- W2227994377 cites W1994008515 @default.
- W2227994377 cites W1994547251 @default.
- W2227994377 cites W1995740716 @default.
- W2227994377 cites W1995831694 @default.
- W2227994377 cites W1996963027 @default.
- W2227994377 cites W2000681816 @default.
- W2227994377 cites W2001193638 @default.
- W2227994377 cites W2001362807 @default.
- W2227994377 cites W2001928601 @default.
- W2227994377 cites W2002801119 @default.
- W2227994377 cites W2003539800 @default.
- W2227994377 cites W2006050677 @default.
- W2227994377 cites W2006246337 @default.
- W2227994377 cites W2006287021 @default.
- W2227994377 cites W2007318901 @default.
- W2227994377 cites W2009494091 @default.
- W2227994377 cites W2009779345 @default.
- W2227994377 cites W2010589854 @default.
- W2227994377 cites W2012726533 @default.
- W2227994377 cites W2013336473 @default.
- W2227994377 cites W2015455914 @default.
- W2227994377 cites W2016117011 @default.
- W2227994377 cites W2017303933 @default.
- W2227994377 cites W2030586664 @default.
- W2227994377 cites W2030679377 @default.
- W2227994377 cites W2032339304 @default.
- W2227994377 cites W2033866966 @default.
- W2227994377 cites W2036131929 @default.
- W2227994377 cites W2040281880 @default.
- W2227994377 cites W2041957427 @default.
- W2227994377 cites W2046836290 @default.
- W2227994377 cites W2048738245 @default.
- W2227994377 cites W2050618347 @default.
- W2227994377 cites W2056105279 @default.
- W2227994377 cites W2059498859 @default.
- W2227994377 cites W2064896421 @default.
- W2227994377 cites W2068375947 @default.
- W2227994377 cites W2069528064 @default.
- W2227994377 cites W2072061544 @default.
- W2227994377 cites W2073394329 @default.
- W2227994377 cites W2075312117 @default.
- W2227994377 cites W2078012627 @default.
- W2227994377 cites W2082872212 @default.
- W2227994377 cites W2083433785 @default.
- W2227994377 cites W2090245491 @default.
- W2227994377 cites W2093987643 @default.
- W2227994377 cites W2095724073 @default.
- W2227994377 cites W2097004047 @default.
- W2227994377 cites W2100804779 @default.
- W2227994377 cites W2102614687 @default.
- W2227994377 cites W2103313927 @default.
- W2227994377 cites W2103743227 @default.
- W2227994377 cites W2103802045 @default.
- W2227994377 cites W2103881507 @default.
- W2227994377 cites W2105444610 @default.
- W2227994377 cites W2106089606 @default.
- W2227994377 cites W2109167188 @default.
- W2227994377 cites W2110101910 @default.
- W2227994377 cites W2110208797 @default.
- W2227994377 cites W2110747672 @default.
- W2227994377 cites W2112383001 @default.
- W2227994377 cites W2117591375 @default.
- W2227994377 cites W2117925162 @default.
- W2227994377 cites W2120182640 @default.
- W2227994377 cites W2124152744 @default.
- W2227994377 cites W2124526585 @default.
- W2227994377 cites W2125210451 @default.
- W2227994377 cites W2127438603 @default.
- W2227994377 cites W2134231388 @default.
- W2227994377 cites W2136794022 @default.