Matches in SemOpenAlex for { <https://semopenalex.org/work/W2228092263> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W2228092263 abstract "Sodium entry during the decaying phase of the action potential determines the metabolic efficiency of a neuron's spiking mechanism. Recent studies have reported that mammalian action potentials are close to metabolic optimality but that fast-spiking inhibitory neurons are less efficient than their pyramidal counterparts. It is postulated that this represents nature's tradeoff between metabolic efficiency and the ability to discharge at high rates. Using eight different published Hodgkin-Huxley models of mammalian neurons to cover a wide range of action potential metabolic efficiencies, we show that the cost of operating a neuron is heavily dependent on its output frequency. We observe that this cost is significantly smaller than the frequency-dependent cost naively estimated from an isolated action potential, the gap increasing with increasing frequencies. Our results demonstrate that metabolic efficiency cannot be considered only in terms of isolated action potentials but must be studied over a range of meaningful frequencies. © 2012 Springer-Verlag." @default.
- W2228092263 created "2016-06-24" @default.
- W2228092263 creator A5001848976 @default.
- W2228092263 creator A5027282431 @default.
- W2228092263 creator A5080659468 @default.
- W2228092263 creator A5086274042 @default.
- W2228092263 date "2012-10-25" @default.
- W2228092263 modified "2023-10-03" @default.
- W2228092263 title "Impact of frequency on the energetic efficiency of action potentials" @default.
- W2228092263 hasPublicationYear "2012" @default.
- W2228092263 type Work @default.
- W2228092263 sameAs 2228092263 @default.
- W2228092263 citedByCount "0" @default.
- W2228092263 crossrefType "journal-article" @default.
- W2228092263 hasAuthorship W2228092263A5001848976 @default.
- W2228092263 hasAuthorship W2228092263A5027282431 @default.
- W2228092263 hasAuthorship W2228092263A5080659468 @default.
- W2228092263 hasAuthorship W2228092263A5086274042 @default.
- W2228092263 hasConcept C121332964 @default.
- W2228092263 hasConcept C134018914 @default.
- W2228092263 hasConcept C159985019 @default.
- W2228092263 hasConcept C169760540 @default.
- W2228092263 hasConcept C186060115 @default.
- W2228092263 hasConcept C192562407 @default.
- W2228092263 hasConcept C204323151 @default.
- W2228092263 hasConcept C2778794669 @default.
- W2228092263 hasConcept C2780791683 @default.
- W2228092263 hasConcept C2992768293 @default.
- W2228092263 hasConcept C33923547 @default.
- W2228092263 hasConcept C62520636 @default.
- W2228092263 hasConcept C86803240 @default.
- W2228092263 hasConceptScore W2228092263C121332964 @default.
- W2228092263 hasConceptScore W2228092263C134018914 @default.
- W2228092263 hasConceptScore W2228092263C159985019 @default.
- W2228092263 hasConceptScore W2228092263C169760540 @default.
- W2228092263 hasConceptScore W2228092263C186060115 @default.
- W2228092263 hasConceptScore W2228092263C192562407 @default.
- W2228092263 hasConceptScore W2228092263C204323151 @default.
- W2228092263 hasConceptScore W2228092263C2778794669 @default.
- W2228092263 hasConceptScore W2228092263C2780791683 @default.
- W2228092263 hasConceptScore W2228092263C2992768293 @default.
- W2228092263 hasConceptScore W2228092263C33923547 @default.
- W2228092263 hasConceptScore W2228092263C62520636 @default.
- W2228092263 hasConceptScore W2228092263C86803240 @default.
- W2228092263 hasOpenAccess W2228092263 @default.
- W2228092263 isParatext "false" @default.
- W2228092263 isRetracted "false" @default.
- W2228092263 magId "2228092263" @default.
- W2228092263 workType "article" @default.