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- W2228409087 abstract "Radiotherapy is the most commonly used local treatment of cancer. However, the large dose needed for local control often limits its successful use. In view of the stimulatory effect of low dose radiation (LDR) on anticancer immunity an experimental study of the effect of whole-body irradiation (WBI) of low doses on the outcome of conventional local radiotherapy of cancer was designed with an aim at reducing the total dose and promoting treatment efficacy. Since radiation doses as low as 0.05 0.1 Gy could stimulate the expression of genes downstream of Egr-1 promoter and gene therapy with Egr-IL-18-B7.1 in combination with local X-rays showed better control of mouse melanoma than local radiotherapy alone, it is desirable to study the effect of introduction of this plasmid in melanoma and Lewis lung cancer models in combination with conventional radiotherapy combined with WBI of low doses. Here we report on the effect of WBI with low doses combined with conventional radiotherapy or gene radiotherapy on reduction of radiation dose together with better cancer control and its possible immunological mechanisms." @default.
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- W2228409087 date "2006-01-01" @default.
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- W2228409087 title "Whole-body Low Dose Irradiation Promotes the Efficacy of Conventional Radiotheray of Cancer and Immunological Mechanisms" @default.
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