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• W2228475819 abstract "Human leukocyte antigen-G (HLA-G) is an anti-inflammatory and immunosuppressive molecule that can modulate immune cell activation. The role of HLA-G in tuberculosis, an immune-mediated and chronic bacterial disease remains to be elucidated. We investigated the expression profile of soluble and membrane bound HLA-G in pulmonary TB (PTB), TB pleural effusion (TB-PE, localized disease) and Miliary TB (disseminated form). The expression of HLA-G receptor, ILT-2 was also determined on the immune cells. We observed that the plasma sHLA-G levels were significantly increased in Miliary TB than in TB-PE patients. In contrast, immunophenotyping revealed that the percent frequency of CD3(+) T cells expressing HLA-G was significantly reduced in Miliary TB as compared to TB-PE, whereas frequency of CD14(+) monocytes expressing HLA-G was significantly higher in TB-PE patients. Strikingly in the TB-PE cases, comparison of disease site, i.e. pleural effusion with peripheral blood showed increased expression of both soluble and surface HLA-G, whereas ILT-2 expressing cells were reduced at the local disease site. Furthermore, we demonstrated that in TB-PE cases, HLA-G expression on CD3(+) T cells was influenced by broad spectrum MMP inhibitor. Thus, differential expression of HLA-G could potentially be a useful biomarker to distinguish different states of TB disease." @default.
• W2228475819 created "2016-06-24" @default.
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• W2228475819 date "2016-09-01" @default.
• W2228475819 modified "2023-09-24" @default.
• W2228475819 title "Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: Localized versus disseminated disease" @default.
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• W2228475819 doi "https://doi.org/10.1016/j.humimm.2016.01.004" @default.
• W2228475819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26776460" @default.
• W2228475819 hasPublicationYear "2016" @default.
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