FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2228497752> ?p ?o ?g. }

• W2228497752 endingPage "124" @default.
• W2228497752 startingPage "118" @default.
• W2228497752 abstract "Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years.A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and socio-behavioural factors.Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p=0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p<0.001), and hs-CRP (p=0.047). Salivary cortisol was associated positively with HDL-C (p=0.033) and negatively with LDL-cholesterol (p=0.016); plasma calculated free cortisol was positively associated with triglycerides (p=0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p<0.001), LDL-cholesterol (p=0.022), and hs-CRP (p=0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity.In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD." @default.
• W2228497752 created "2016-06-24" @default.
• W2228497752 creator A5020589300 @default.
• W2228497752 creator A5024230104 @default.
• W2228497752 creator A5032904180 @default.
• W2228497752 creator A5045012584 @default.
• W2228497752 creator A5071397090 @default.
• W2228497752 creator A5073870478 @default.
• W2228497752 creator A5075154828 @default.
• W2228497752 creator A5076433645 @default.
• W2228497752 creator A5087973871 @default.
• W2228497752 date "2016-04-01" @default.
• W2228497752 modified "2023-09-24" @default.
• W2228497752 title "Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents" @default.
• W2228497752 cites W1732425222 @default.
• W2228497752 cites W1967090449 @default.
• W2228497752 cites W1967239215 @default.
• W2228497752 cites W1971472848 @default.
• W2228497752 cites W1973926831 @default.
• W2228497752 cites W1983099697 @default.
• W2228497752 cites W1985211733 @default.
• W2228497752 cites W1987951226 @default.
• W2228497752 cites W1996935003 @default.
• W2228497752 cites W1997644403 @default.
• W2228497752 cites W1998742722 @default.
• W2228497752 cites W2020512725 @default.
• W2228497752 cites W2046179952 @default.
• W2228497752 cites W2046350184 @default.
• W2228497752 cites W2048336627 @default.
• W2228497752 cites W2053197646 @default.
• W2228497752 cites W2055336991 @default.
• W2228497752 cites W2057467049 @default.
• W2228497752 cites W2061855053 @default.
• W2228497752 cites W2064663549 @default.
• W2228497752 cites W2069417933 @default.
• W2228497752 cites W2074450558 @default.
• W2228497752 cites W2078881833 @default.
• W2228497752 cites W2083896472 @default.
• W2228497752 cites W2086572104 @default.
• W2228497752 cites W2090916457 @default.
• W2228497752 cites W2094316730 @default.
• W2228497752 cites W2109018676 @default.
• W2228497752 cites W2110243778 @default.
• W2228497752 cites W2116571340 @default.
• W2228497752 cites W2120658378 @default.
• W2228497752 cites W2126551827 @default.
• W2228497752 cites W2130274458 @default.
• W2228497752 cites W2133188156 @default.
• W2228497752 cites W2135670457 @default.
• W2228497752 cites W2142975373 @default.
• W2228497752 cites W2146443705 @default.
• W2228497752 cites W2149257689 @default.
• W2228497752 cites W2153263515 @default.
• W2228497752 cites W2161278149 @default.
• W2228497752 cites W2162557461 @default.
• W2228497752 cites W2163092745 @default.
• W2228497752 cites W2163853967 @default.
• W2228497752 cites W2169771574 @default.
• W2228497752 cites W2315613231 @default.
• W2228497752 doi "https://doi.org/10.1016/j.psyneuen.2016.01.002" @default.
• W2228497752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26802599" @default.
• W2228497752 hasPublicationYear "2016" @default.
• W2228497752 type Work @default.
• W2228497752 sameAs 2228497752 @default.
• W2228497752 citedByCount "15" @default.
• W2228497752 countsByYear W22284977522017 @default.
• W2228497752 countsByYear W22284977522018 @default.
• W2228497752 countsByYear W22284977522019 @default.
• W2228497752 countsByYear W22284977522020 @default.
• W2228497752 countsByYear W22284977522021 @default.
• W2228497752 countsByYear W22284977522022 @default.
• W2228497752 crossrefType "journal-article" @default.
• W2228497752 hasAuthorship W2228497752A5020589300 @default.
• W2228497752 hasAuthorship W2228497752A5024230104 @default.
• W2228497752 hasAuthorship W2228497752A5032904180 @default.
• W2228497752 hasAuthorship W2228497752A5045012584 @default.
• W2228497752 hasAuthorship W2228497752A5071397090 @default.
• W2228497752 hasAuthorship W2228497752A5073870478 @default.
• W2228497752 hasAuthorship W2228497752A5075154828 @default.
• W2228497752 hasAuthorship W2228497752A5076433645 @default.
• W2228497752 hasAuthorship W2228497752A5087973871 @default.
• W2228497752 hasConcept C126322002 @default.
• W2228497752 hasConcept C134018914 @default.
• W2228497752 hasConcept C2778163477 @default.
• W2228497752 hasConcept C2778709874 @default.
• W2228497752 hasConcept C2908647359 @default.
• W2228497752 hasConcept C50440223 @default.
• W2228497752 hasConcept C71924100 @default.
• W2228497752 hasConcept C81358767 @default.
• W2228497752 hasConcept C84393581 @default.
• W2228497752 hasConcept C90134679 @default.
• W2228497752 hasConcept C99454951 @default.
• W2228497752 hasConceptScore W2228497752C126322002 @default.
• W2228497752 hasConceptScore W2228497752C134018914 @default.
• W2228497752 hasConceptScore W2228497752C2778163477 @default.
• W2228497752 hasConceptScore W2228497752C2778709874 @default.
• W2228497752 hasConceptScore W2228497752C2908647359 @default.
• W2228497752 hasConceptScore W2228497752C50440223 @default.

• next