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• W2228728120 abstract "Atherosclerosis is usually the underlying cause of a fatal event such as myocardial infarction or ictus. The atherome plaque develops silently and asymptomatically within the arterial intima layer. In this context, the possibility to analyze the molecular content of arterial tissue while preserving each molecule’s specific localization is of great interest as it may reveal further insights into the physiopathological changes taking place. Mass spectrometry imaging (MSI) enables the spatially resolved molecular analysis of proteins, peptides, metabolites, lipids and drugs directly in tissue, with a resolution sufficient to reveal molecular features specific to distinct arterial structures. MSI represents a novel ex vivo imaging tool still underexplored in cardiovascular diseases. This review focuses on the MSI technique applied to cardiovascular disease and covers the main contributions to date, ongoing efforts, the main challenges and current limitations of MSI." @default.
• W2228728120 created "2016-06-24" @default.
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• W2228728120 date "2015-12-04" @default.
• W2228728120 modified "2023-10-17" @default.
• W2228728120 title "Molecular histology of arteries: mass spectrometry imaging as a novel<i>ex vivo</i>tool to investigate atherosclerosis" @default.
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• W2228728120 doi "https://doi.org/10.1586/14789450.2016.1116944" @default.
• W2228728120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26558814" @default.
• W2228728120 hasPublicationYear "2015" @default.
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