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• W2228734812 abstract "Acinetobacter baumannii is an important opportunistic bacterial pathogen responsible for serious infections in hospitalized patients. From a total of 78 consecutive non-repetitive Acinetobacter spp. isolates from patients with blood infections, 61 were carbapenem resistant, which were positive for bla OXA-51-like (96.7 %), bla OXA-23-like (77 %), bla OXA-58-like (8.1 %) and bla OXA-40-like genes (32.8 %) by multiplex PCR. The isolates were identified as A. baumannii (n = 59) and Acinetobacter nosocomialis (n = 2). Also, we found a case of Acinetobacter junii, causing bacteraemia, that possessed the IMP gene. High levels of resistance were observed to fluoroquinolones, aminoglycosides, tigecycline and to the beta-lactam antibiotics, including piperacillin/tazobactam and ampicillin/sulbactam. ISAba1 was present in 96.7 % of all Acinetobacter calcoaceticus–baumannii complex (Acb) isolates. Also, 33 (54.1 %) and 23 (37.7 %) isolates harboured ISAba1 upstream of bla OXA-23-like and bla OXA-51-like genes, respectively, though this was not observed in A. nosocomialis isolates. No relationship was observed between the presence of ISAba1 upstream of oxacillinase genes and the level of carbapenem resistance in all Acb isolates. Only two genes encoding metallo-beta-lactamase (VIM, SPM) were detected in all Acb isolates. This suggests that carbapenem resistance in blood-isolate Acb is mostly due to the presence of acquired carbapenemases. This is the first report from Iran on the identification of A. nosocomialis isolates that possess multiple oxacillinase genes and lack upstream ISAba1." @default.
• W2228734812 created "2016-06-24" @default.
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• W2228734812 date "2016-03-01" @default.
• W2228734812 modified "2023-09-27" @default.
• W2228734812 title "Characterization of carbapenem-resistant Acinetobacter calcoaceticus–baumannii complex isolates from nosocomial bloodstream infections in southern Iran" @default.
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• W2228734812 doi "https://doi.org/10.1099/jmm.0.000219" @default.
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