FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2228914458> ?p ?o ?g. }

• W2228914458 abstract "In their recent systematic review and meta-analysis, Nagaraja and colleagues support the use of self-expanding metal stents (SEMS) in patients with oesophageal malignancy undergoing neoadjuvant therapy prior to potentially curative oesophagectomy as ‘safe and effective’ (1). Summarising the results of nine studies comprising 180 patients, the authors identify both a significant reduction in dysphagia and matched increases in weight and serum albumin in patients treated with SEMS insertion. There is, however, a substantial body of evidence to demonstrate a myriad of adverse events resulting directly from the use of oesophageal stents which we believe should preclude their use for the relief of dysphagia in patients awaiting curative resection.Nagaraja and colleagues report the incidence of stent migration in their study to equal 32%, attributed to tumour response from neoadjuvant therapy. This figure masks significant rates of unplanned reintervention for stent revision, exchange or removal noted within series published by Adler et al., Lopes et al., Langer et al., Martin et al. and Siddiqui et al. (2-6). At best, this may inconvenience patients and delay neoadjuvant therapy whilst, at worst, emergency laparotomy is required to prevent or treat small bowel perforation.There are additional reports of severe adverse effects directly related to the presence of an oesophageal stent in an otherwise potentially curable patient. Within a series of 16 patients undergoing stent insertion, Christie and colleagues reported one case of stent erosion in to a vertebral body, which made surgery more difficult, and death resulting from mediastinal sepsis secondary to a mediastinal abscess formed following occult perforation caused by a stent (7). The risk of local anatomical disruption is supported by Langer and colleagues’ 2010 series of 38 patients which notes five serious complications resulting from stent use, including two oesophago-tracheobronchial fistulae, one acute oesophageal perforation, one small bowel perforation and one erosion of the aortic wall (4). Lopes et al. additionally makes note of a case of tracheoesophageal fistulation occurring within a series of ten patients (3). Even in patients who are unaffected by these life threatening complications other authors have noted difficult tissue planes during oesophagectomy in patients who have been treated with stents.A more common complication of stent insertion noted by the authors is one of chest discomfort, which occurred in 51% of their cohort. Although commonly reported to be self-limiting and readily relieved with oral analgesia, there are within the literature cited by Nagaraja a number of reports of significant chest pain which has followed stent insertion and subsequently necessitated emergency removal (1).Even in those who do not develop an adverse effect associated with stent insertion, their use appears marred by the potential for compromising survival and overall progression to surgery. Randomised analyses have revealed worse survival in patients with palliative oesophageal malignancy who receive metal stents, rather than alternative approaches for the relief of dysphagia (8). No similar analysis of survival or rates of progression to surgery is afforded by Nagaraja et al.’s analysis, yet progression to surgical resection is reported within series they cite to be as low as 15%. This may be due to the advanced nature of the tumours stented, however a direct effect of the stent cannot be discounted. There is interesting data from patients with colorectal cancer which highlights an increase in the number of free tumour cells within the circulation following stent insertion, a phenomenon considered secondary to mechanical stress imposed on the tumour body (9).Whilst the improvement in dysphagia, weight and serum albumin reported by Nagaraja et al. appears to afford promise in the management of patients with dysphagia undergoing neoadjuvant therapy, clinicians must apply caution to its interpretation in light of the above comments. There is a clear need for randomised controlled trial to compare oesophageal stents of all materials to alternative strategies (such as nasogastric tube or feeding jejunostomy) to relieve dysphagia in potentially curative patients undergoing neoadjuvant therapy." @default.
• W2228914458 created "2016-06-24" @default.
• W2228914458 creator A5018067437 @default.
• W2228914458 creator A5075442932 @default.
• W2228914458 date "2014-08-01" @default.
• W2228914458 modified "2023-09-23" @default.
• W2228914458 title "Safety implications of oesophageal stents used for the palliation of dysphagia in patients undergoing neoadjuvant therapy for oesophageal malignancy." @default.
• W2228914458 cites W1579793251 @default.
• W2228914458 cites W1843120051 @default.
• W2228914458 cites W1984758011 @default.
• W2228914458 cites W2004168368 @default.
• W2228914458 cites W2038679183 @default.
• W2228914458 cites W2038786693 @default.
• W2228914458 cites W2051226455 @default.
• W2228914458 cites W2082142659 @default.
• W2228914458 cites W2141942243 @default.
• W2228914458 doi "https://doi.org/10.3978/j.issn.2078-6891.2014.035" @default.
• W2228914458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4110487" @default.
• W2228914458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25083305" @default.
• W2228914458 hasPublicationYear "2014" @default.
• W2228914458 type Work @default.
• W2228914458 sameAs 2228914458 @default.
• W2228914458 citedByCount "1" @default.
• W2228914458 countsByYear W22289144582017 @default.
• W2228914458 crossrefType "journal-article" @default.
• W2228914458 hasAuthorship W2228914458A5018067437 @default.
• W2228914458 hasAuthorship W2228914458A5075442932 @default.
• W2228914458 hasConcept C120665830 @default.
• W2228914458 hasConcept C121332964 @default.
• W2228914458 hasConcept C121608353 @default.
• W2228914458 hasConcept C126322002 @default.
• W2228914458 hasConcept C141071460 @default.
• W2228914458 hasConcept C191897082 @default.
• W2228914458 hasConcept C192562407 @default.
• W2228914458 hasConcept C197934379 @default.
• W2228914458 hasConcept C2776204476 @default.
• W2228914458 hasConcept C2777297899 @default.
• W2228914458 hasConcept C2778292576 @default.
• W2228914458 hasConcept C2778456384 @default.
• W2228914458 hasConcept C2778527123 @default.
• W2228914458 hasConcept C2778583881 @default.
• W2228914458 hasConcept C2779399171 @default.
• W2228914458 hasConcept C2779742542 @default.
• W2228914458 hasConcept C2780596822 @default.
• W2228914458 hasConcept C530470458 @default.
• W2228914458 hasConcept C61434518 @default.
• W2228914458 hasConcept C61511704 @default.
• W2228914458 hasConcept C71924100 @default.
• W2228914458 hasConceptScore W2228914458C120665830 @default.
• W2228914458 hasConceptScore W2228914458C121332964 @default.
• W2228914458 hasConceptScore W2228914458C121608353 @default.
• W2228914458 hasConceptScore W2228914458C126322002 @default.
• W2228914458 hasConceptScore W2228914458C141071460 @default.
• W2228914458 hasConceptScore W2228914458C191897082 @default.
• W2228914458 hasConceptScore W2228914458C192562407 @default.
• W2228914458 hasConceptScore W2228914458C197934379 @default.
• W2228914458 hasConceptScore W2228914458C2776204476 @default.
• W2228914458 hasConceptScore W2228914458C2777297899 @default.
• W2228914458 hasConceptScore W2228914458C2778292576 @default.
• W2228914458 hasConceptScore W2228914458C2778456384 @default.
• W2228914458 hasConceptScore W2228914458C2778527123 @default.
• W2228914458 hasConceptScore W2228914458C2778583881 @default.
• W2228914458 hasConceptScore W2228914458C2779399171 @default.
• W2228914458 hasConceptScore W2228914458C2779742542 @default.
• W2228914458 hasConceptScore W2228914458C2780596822 @default.
• W2228914458 hasConceptScore W2228914458C530470458 @default.
• W2228914458 hasConceptScore W2228914458C61434518 @default.
• W2228914458 hasConceptScore W2228914458C61511704 @default.
• W2228914458 hasConceptScore W2228914458C71924100 @default.
• W2228914458 hasLocation W22289144581 @default.
• W2228914458 hasOpenAccess W2228914458 @default.
• W2228914458 hasPrimaryLocation W22289144581 @default.
• W2228914458 hasRelatedWork W1642379033 @default.
• W2228914458 hasRelatedWork W1966449081 @default.
• W2228914458 hasRelatedWork W2054280481 @default.
• W2228914458 hasRelatedWork W2087866032 @default.
• W2228914458 hasRelatedWork W2143192850 @default.
• W2228914458 hasRelatedWork W2187198565 @default.
• W2228914458 hasRelatedWork W2234207065 @default.
• W2228914458 hasRelatedWork W2329819989 @default.
• W2228914458 hasRelatedWork W2334075753 @default.
• W2228914458 hasRelatedWork W2365607115 @default.
• W2228914458 hasRelatedWork W2412111907 @default.
• W2228914458 hasRelatedWork W2416534104 @default.
• W2228914458 hasRelatedWork W2416936869 @default.
• W2228914458 hasRelatedWork W2438028715 @default.
• W2228914458 hasRelatedWork W2438608501 @default.
• W2228914458 hasRelatedWork W2464170798 @default.
• W2228914458 hasRelatedWork W2885057283 @default.
• W2228914458 hasRelatedWork W2899714083 @default.
• W2228914458 hasRelatedWork W2914842246 @default.
• W2228914458 hasRelatedWork W2946209607 @default.
• W2228914458 isParatext "false" @default.
• W2228914458 isRetracted "false" @default.
• W2228914458 magId "2228914458" @default.
• W2228914458 workType "article" @default.