Matches in SemOpenAlex for { <https://semopenalex.org/work/W2229017165> ?p ?o ?g. }
- W2229017165 endingPage "213" @default.
- W2229017165 startingPage "192" @default.
- W2229017165 abstract "Cannabinoid administration before and after simian immunodeficiency virus (SIV)-inoculation ameliorated disease progression and decreased inflammation in male rhesus macaques. Δ9-tetrahydrocannabinol (Δ9-THC) did not increase viral load in brain tissue or produce additive neuropsychological impairment in SIV-infected macaques. To determine if the neuroimmunomodulation of Δ9-THC involved differential microRNA (miR) expression, miR expression in the striatum of uninfected macaques receiving vehicle (VEH) or Δ9-THC (THC) and SIV-infected macaques administered either vehicle (VEH/SIV) or Δ9-THC (THC/SIV) was profiled using next generation deep sequencing. Among the 24 miRs that were differentially expressed among the four groups, 16 miRs were modulated by THC in the presence of SIV. These 16 miRs were classified into four categories and the biological processes enriched by the target genes determined. Our results indicate that Δ9-THC modulates miRs that regulate mRNAs of proteins involved in 1) neurotrophin signaling, 2) MAPK signaling, and 3) cell cycle and immune response thus promoting an overall neuroprotective environment in the striatum of SIV-infected macaques. This is also reflected by increased Brain Derived Neurotrophic Factor (BDNF) and decreased proinflammatory cytokine expression compared to the VEH/SIV group. Whether Δ9-THC-mediated modulation of epigenetic mechanisms provides neuroprotection in other regions of the brain and during chronic SIV-infection remains to be determined." @default.
- W2229017165 created "2016-06-24" @default.
- W2229017165 creator A5010642130 @default.
- W2229017165 creator A5014007269 @default.
- W2229017165 creator A5027281273 @default.
- W2229017165 creator A5031854630 @default.
- W2229017165 creator A5049339126 @default.
- W2229017165 creator A5052960857 @default.
- W2229017165 creator A5068516229 @default.
- W2229017165 creator A5075838086 @default.
- W2229017165 date "2015-11-25" @default.
- W2229017165 modified "2023-10-16" @default.
- W2229017165 title "Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques" @default.
- W2229017165 cites W1458955562 @default.
- W2229017165 cites W1692149261 @default.
- W2229017165 cites W1708150772 @default.
- W2229017165 cites W1849091229 @default.
- W2229017165 cites W1946520978 @default.
- W2229017165 cites W1965058833 @default.
- W2229017165 cites W1978155055 @default.
- W2229017165 cites W1980079641 @default.
- W2229017165 cites W1985785712 @default.
- W2229017165 cites W1986411839 @default.
- W2229017165 cites W1993412416 @default.
- W2229017165 cites W1994357966 @default.
- W2229017165 cites W1995777463 @default.
- W2229017165 cites W2002669868 @default.
- W2229017165 cites W2003770019 @default.
- W2229017165 cites W2005807968 @default.
- W2229017165 cites W2010722062 @default.
- W2229017165 cites W2020986481 @default.
- W2229017165 cites W2025065138 @default.
- W2229017165 cites W2025725983 @default.
- W2229017165 cites W2025902983 @default.
- W2229017165 cites W2028794666 @default.
- W2229017165 cites W2031374798 @default.
- W2229017165 cites W2031846098 @default.
- W2229017165 cites W2037114802 @default.
- W2229017165 cites W2061105740 @default.
- W2229017165 cites W2061130785 @default.
- W2229017165 cites W2063358396 @default.
- W2229017165 cites W2069261423 @default.
- W2229017165 cites W2075661792 @default.
- W2229017165 cites W2080888722 @default.
- W2229017165 cites W2090912451 @default.
- W2229017165 cites W2099716759 @default.
- W2229017165 cites W2101925441 @default.
- W2229017165 cites W2102340949 @default.
- W2229017165 cites W2103247095 @default.
- W2229017165 cites W2104488717 @default.
- W2229017165 cites W2107224229 @default.
- W2229017165 cites W2109169003 @default.
- W2229017165 cites W2115118763 @default.
- W2229017165 cites W2119177972 @default.
- W2229017165 cites W2121764727 @default.
- W2229017165 cites W2124024269 @default.
- W2229017165 cites W2128016314 @default.
- W2229017165 cites W2129299187 @default.
- W2229017165 cites W2129643089 @default.
- W2229017165 cites W2130276206 @default.
- W2229017165 cites W2133465414 @default.
- W2229017165 cites W2133763262 @default.
- W2229017165 cites W2136435696 @default.
- W2229017165 cites W2139655181 @default.
- W2229017165 cites W2140465783 @default.
- W2229017165 cites W2142663409 @default.
- W2229017165 cites W2146997290 @default.
- W2229017165 cites W2148950534 @default.
- W2229017165 cites W2150445069 @default.
- W2229017165 cites W2156899450 @default.
- W2229017165 cites W2157173581 @default.
- W2229017165 cites W2158217645 @default.
- W2229017165 cites W2161782628 @default.
- W2229017165 cites W2162082544 @default.
- W2229017165 cites W2164965868 @default.
- W2229017165 cites W2166209080 @default.
- W2229017165 cites W2315888296 @default.
- W2229017165 cites W2325077524 @default.
- W2229017165 cites W2407686950 @default.
- W2229017165 cites W2409385743 @default.
- W2229017165 doi "https://doi.org/10.1007/s11481-015-9645-6" @default.
- W2229017165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773048" @default.
- W2229017165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26607731" @default.
- W2229017165 hasPublicationYear "2015" @default.
- W2229017165 type Work @default.
- W2229017165 sameAs 2229017165 @default.
- W2229017165 citedByCount "19" @default.
- W2229017165 countsByYear W22290171652017 @default.
- W2229017165 countsByYear W22290171652018 @default.
- W2229017165 countsByYear W22290171652019 @default.
- W2229017165 countsByYear W22290171652020 @default.
- W2229017165 countsByYear W22290171652021 @default.
- W2229017165 countsByYear W22290171652022 @default.
- W2229017165 countsByYear W22290171652023 @default.
- W2229017165 crossrefType "journal-article" @default.
- W2229017165 hasAuthorship W2229017165A5010642130 @default.
- W2229017165 hasAuthorship W2229017165A5014007269 @default.
- W2229017165 hasAuthorship W2229017165A5027281273 @default.