Matches in SemOpenAlex for { <https://semopenalex.org/work/W2229084712> ?p ?o ?g. }
- W2229084712 endingPage "473" @default.
- W2229084712 startingPage "455" @default.
- W2229084712 abstract "Since their first descriptions, ion channels have been conceived as proteinaceous conduits that facilitate the passage of ionic cargo between segregated environments. This concept is reinforced by crystallographic structures of cation channels depicting ion conductance pathways completely lined by protein. Although lipids are sometimes present in fenestrations near the pore or may be involved in channel gating, there is little or no evidence that lipids inhabit the ion conduction pathway. Indeed, the presence of lipid acyl chains in the conductance pathway would curse the design of the channel's aqueous pore. Here, we make a speculative proposal that anion channels in the TMEM16/ANO superfamily have ion conductance pathways composed partly of lipids. Our reasoning is based on the idea that TMEM16 ion channels evolved from a kind of lipid transporter that scrambles lipids between leaflets of the membrane bilayer and the modeled structural similarity between TMEM16 lipid scramblases and TMEM16 anion channels. This novel view of the TMEM16 pore offers explanation for the biophysical and pharmacological oddness of TMEM16A. We build upon the recent X-ray structure of nhTMEM16 and develop models of both TMEM16 ion channels and lipid scramblases to bolster our proposal. It is our hope that this model of the TMEM16 pore will foster innovative investigation into TMEM16 function." @default.
- W2229084712 created "2016-06-24" @default.
- W2229084712 creator A5037972336 @default.
- W2229084712 creator A5072928814 @default.
- W2229084712 date "2016-01-06" @default.
- W2229084712 modified "2023-10-17" @default.
- W2229084712 title "A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid" @default.
- W2229084712 cites W1493374012 @default.
- W2229084712 cites W1498095761 @default.
- W2229084712 cites W1515820929 @default.
- W2229084712 cites W1527429236 @default.
- W2229084712 cites W1527592070 @default.
- W2229084712 cites W1530392181 @default.
- W2229084712 cites W1534596534 @default.
- W2229084712 cites W1536640324 @default.
- W2229084712 cites W1849347232 @default.
- W2229084712 cites W1868383480 @default.
- W2229084712 cites W1926436230 @default.
- W2229084712 cites W1940692702 @default.
- W2229084712 cites W1965361683 @default.
- W2229084712 cites W1967506638 @default.
- W2229084712 cites W1967510354 @default.
- W2229084712 cites W1968188734 @default.
- W2229084712 cites W1970425525 @default.
- W2229084712 cites W1971217771 @default.
- W2229084712 cites W1973662152 @default.
- W2229084712 cites W1975274813 @default.
- W2229084712 cites W1976976361 @default.
- W2229084712 cites W1978963713 @default.
- W2229084712 cites W1979196237 @default.
- W2229084712 cites W1980591355 @default.
- W2229084712 cites W1980939512 @default.
- W2229084712 cites W1981193117 @default.
- W2229084712 cites W1987018129 @default.
- W2229084712 cites W1990636786 @default.
- W2229084712 cites W1990973079 @default.
- W2229084712 cites W1994789732 @default.
- W2229084712 cites W1995332683 @default.
- W2229084712 cites W1997518841 @default.
- W2229084712 cites W1999317859 @default.
- W2229084712 cites W1999513543 @default.
- W2229084712 cites W2000178601 @default.
- W2229084712 cites W2005040236 @default.
- W2229084712 cites W2005859080 @default.
- W2229084712 cites W2005975940 @default.
- W2229084712 cites W2007567749 @default.
- W2229084712 cites W2007767060 @default.
- W2229084712 cites W2008804874 @default.
- W2229084712 cites W2008964034 @default.
- W2229084712 cites W2013853780 @default.
- W2229084712 cites W2014279568 @default.
- W2229084712 cites W2014374660 @default.
- W2229084712 cites W2017197907 @default.
- W2229084712 cites W2017719480 @default.
- W2229084712 cites W2020291681 @default.
- W2229084712 cites W2020754695 @default.
- W2229084712 cites W2021882008 @default.
- W2229084712 cites W2022188694 @default.
- W2229084712 cites W2025489455 @default.
- W2229084712 cites W2027033796 @default.
- W2229084712 cites W2028475005 @default.
- W2229084712 cites W2032434028 @default.
- W2229084712 cites W2034766199 @default.
- W2229084712 cites W2038619375 @default.
- W2229084712 cites W2041185002 @default.
- W2229084712 cites W2043779911 @default.
- W2229084712 cites W2048266170 @default.
- W2229084712 cites W2049314578 @default.
- W2229084712 cites W2052090852 @default.
- W2229084712 cites W2055401750 @default.
- W2229084712 cites W2058530636 @default.
- W2229084712 cites W2060259273 @default.
- W2229084712 cites W2060891750 @default.
- W2229084712 cites W2061372386 @default.
- W2229084712 cites W2065417952 @default.
- W2229084712 cites W2066013154 @default.
- W2229084712 cites W2068749469 @default.
- W2229084712 cites W2069109961 @default.
- W2229084712 cites W2071581047 @default.
- W2229084712 cites W2071782007 @default.
- W2229084712 cites W2072130252 @default.
- W2229084712 cites W2078571865 @default.
- W2229084712 cites W2080689645 @default.
- W2229084712 cites W2080876886 @default.
- W2229084712 cites W2083482378 @default.
- W2229084712 cites W2084963424 @default.
- W2229084712 cites W2085178645 @default.
- W2229084712 cites W2086589360 @default.
- W2229084712 cites W2086611521 @default.
- W2229084712 cites W2087791794 @default.
- W2229084712 cites W2088697121 @default.
- W2229084712 cites W2091122219 @default.
- W2229084712 cites W2091437674 @default.
- W2229084712 cites W2092544515 @default.
- W2229084712 cites W2092692878 @default.
- W2229084712 cites W2092868876 @default.
- W2229084712 cites W2093818973 @default.
- W2229084712 cites W2094337309 @default.