FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2229127986> ?p ?o ?g. }

• W2229127986 endingPage "69" @default.
• W2229127986 startingPage "58" @default.
• W2229127986 abstract "Biopersistence of carbon nanotubes, graphene oxide (GO) and several other types of carbonaceous nanomaterials is an essential determinant of their health effects. Successful biodegradation is one of the major factors defining the life span and biological responses to nanoparticles. Here, we review the role and contribution of different oxidative enzymes of inflammatory cells - myeloperoxidase, eosinophil peroxidase, lactoperoxidase, hemoglobin, and xanthine oxidase - to the reactions of nanoparticle biodegradation. We further focus on interactions of nanomaterials with hemoproteins dependent on the specific features of their physico-chemical and structural characteristics. Mechanistically, we highlight the significance of immobilized peroxidase reactive intermediates vs diffusible small molecule oxidants (hypochlorous and hypobromous acids) for the overall oxidative biodegradation process in neutrophils and eosinophils. We also accentuate the importance of peroxynitrite-driven pathways realized in macrophages via the engagement of NADPH oxidase- and NO synthase-triggered oxidative mechanisms. We consider possible involvement of oxidative machinery of other professional phagocytes such as microglial cells, myeloid-derived suppressor cells, in the context of biodegradation relevant to targeted drug delivery. We evaluate the importance of genetic factors and their manipulations for the enzymatic biodegradation in vivo. Finally, we emphasize a novel type of biodegradation realized via the activation of the dormant peroxidase activity of hemoproteins by the nano-surface. This is exemplified by the binding of GO to cyt c causing the unfolding and 'unmasking' of the peroxidase activity of the latter. We conclude with the strategies leading to safe by design carbonaceous nanoparticles with optimized characteristics for mechanism-based targeted delivery and regulatable life-span of drugs in circulation." @default.
• W2229127986 created "2016-06-24" @default.
• W2229127986 creator A5002182132 @default.
• W2229127986 creator A5017495198 @default.
• W2229127986 creator A5025786667 @default.
• W2229127986 creator A5041746083 @default.
• W2229127986 creator A5056357921 @default.
• W2229127986 creator A5058519299 @default.
• W2229127986 creator A5062507720 @default.
• W2229127986 creator A5069406228 @default.
• W2229127986 date "2016-05-01" @default.
• W2229127986 modified "2023-10-11" @default.
• W2229127986 title "Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications" @default.
• W2229127986 cites W1124131556 @default.
• W2229127986 cites W1193140474 @default.
• W2229127986 cites W140184338 @default.
• W2229127986 cites W1499452131 @default.
• W2229127986 cites W1528874167 @default.
• W2229127986 cites W1539435229 @default.
• W2229127986 cites W1717542398 @default.
• W2229127986 cites W1777061694 @default.
• W2229127986 cites W1806770925 @default.
• W2229127986 cites W1946760493 @default.
• W2229127986 cites W1963890761 @default.
• W2229127986 cites W1963907102 @default.
• W2229127986 cites W1964237645 @default.
• W2229127986 cites W1966845383 @default.
• W2229127986 cites W1967109235 @default.
• W2229127986 cites W1967427818 @default.
• W2229127986 cites W1970216947 @default.
• W2229127986 cites W1971282120 @default.
• W2229127986 cites W1971435128 @default.
• W2229127986 cites W1973831032 @default.
• W2229127986 cites W1974597641 @default.
• W2229127986 cites W1977914031 @default.
• W2229127986 cites W1979711098 @default.
• W2229127986 cites W1980199670 @default.
• W2229127986 cites W1985052577 @default.
• W2229127986 cites W1985674024 @default.
• W2229127986 cites W1991046381 @default.
• W2229127986 cites W1994646181 @default.
• W2229127986 cites W1995279009 @default.
• W2229127986 cites W1996168808 @default.
• W2229127986 cites W1996468289 @default.
• W2229127986 cites W1996566409 @default.
• W2229127986 cites W2000200761 @default.
• W2229127986 cites W2001537125 @default.
• W2229127986 cites W2002437297 @default.
• W2229127986 cites W2005685299 @default.
• W2229127986 cites W2005985941 @default.
• W2229127986 cites W2010265091 @default.
• W2229127986 cites W2010427019 @default.
• W2229127986 cites W2011162707 @default.
• W2229127986 cites W2011825171 @default.
• W2229127986 cites W2013150924 @default.
• W2229127986 cites W2014263047 @default.
• W2229127986 cites W2016941411 @default.
• W2229127986 cites W2019106185 @default.
• W2229127986 cites W2019985255 @default.
• W2229127986 cites W2022377100 @default.
• W2229127986 cites W2023403718 @default.
• W2229127986 cites W2023960156 @default.
• W2229127986 cites W2029704380 @default.
• W2229127986 cites W2031639594 @default.
• W2229127986 cites W2035166438 @default.
• W2229127986 cites W2036459756 @default.
• W2229127986 cites W2041701381 @default.
• W2229127986 cites W2042596032 @default.
• W2229127986 cites W2043461710 @default.
• W2229127986 cites W2043771728 @default.
• W2229127986 cites W2044571611 @default.
• W2229127986 cites W2044880694 @default.
• W2229127986 cites W2046060561 @default.
• W2229127986 cites W2046768022 @default.
• W2229127986 cites W2046851174 @default.
• W2229127986 cites W2046963338 @default.
• W2229127986 cites W2048456951 @default.
• W2229127986 cites W2050886209 @default.
• W2229127986 cites W2053498385 @default.
• W2229127986 cites W2057673505 @default.
• W2229127986 cites W2060672294 @default.
• W2229127986 cites W2061242359 @default.
• W2229127986 cites W2061547898 @default.
• W2229127986 cites W2062897750 @default.
• W2229127986 cites W2068041381 @default.
• W2229127986 cites W2072002791 @default.
• W2229127986 cites W2072135901 @default.
• W2229127986 cites W2073974612 @default.
• W2229127986 cites W2074621487 @default.
• W2229127986 cites W2077397427 @default.
• W2229127986 cites W2078631959 @default.
• W2229127986 cites W2079220574 @default.
• W2229127986 cites W2079240588 @default.
• W2229127986 cites W2079365412 @default.
• W2229127986 cites W2079609666 @default.
• W2229127986 cites W2084215933 @default.
• W2229127986 cites W2084287411 @default.
• W2229127986 cites W2084388967 @default.

• next