Matches in SemOpenAlex for { <https://semopenalex.org/work/W2229539623> ?p ?o ?g. }
- W2229539623 endingPage "3233" @default.
- W2229539623 startingPage "3222" @default.
- W2229539623 abstract "Abstract Graft rejection in allogeneic bone marrow transplantation (BMT) can occur when donor and recipient are mismatched at one or more major histocompatibility complex (MHC) loci. Donor T cells can prevent graft rejection, but may cause fatal graft-versus-host disease (GVHD). We tested whether irradiation of allogeneic donor lymphocytes would preserve their graft-facilitating activity while inhibiting their potential for GVHD. Infusions of irradiated allogeneic T cells did not cause GVHD in MHC-mismatched SJL → (SJL × C57BL6) F1, C57BL6 → B10.RIII, and C57BL6 → B10.BR mouse donor → recipient BMT pairs. The 60-day survival among MHC-mismatched transplant recipients increased from 2% (BM alone) to up to 75% among recipients of BM plus irradiated allogeneic splenocytes. Optimal results were obtained using 50 × 106 to 75 × 106 irradiated donor splenocytes administered in multiple injections from day −1 to day +1. Recipients of an equal number of nonirradiated MHC-mismatched donor splenocytes uniformly died of acute GVHD. The graft facilitating activity of the irradiated allogeneic splenocytes was mediated by donor T cells. Irradiation to 7.5 Gy increased nuclear NFκB in T cells and their allospecific cytotoxicity. Irradiated T cells survived up to 3 days in the BM of MHC-mismatched recipients without proliferation. Recipients of irradiated allogeneic splenocytes and allogeneic BM had stable donor-derived hematopoiesis without a significant representation of donor splenocytes in the T-cell compartment. Irradiated allogeneic T cells thus represent a form of cellular immunotherapy with time-limited biologic activity in vivo that can facilitate allogeneic BMT without causing GVHD." @default.
- W2229539623 created "2016-06-24" @default.
- W2229539623 creator A5011386306 @default.
- W2229539623 creator A5017056576 @default.
- W2229539623 creator A5023276777 @default.
- W2229539623 creator A5026075876 @default.
- W2229539623 creator A5027017698 @default.
- W2229539623 creator A5029572476 @default.
- W2229539623 creator A5053781658 @default.
- W2229539623 creator A5068525415 @default.
- W2229539623 creator A5089046175 @default.
- W2229539623 date "1999-11-01" @default.
- W2229539623 modified "2023-10-01" @default.
- W2229539623 title "Irradiated Donor Leukocytes Promote Engraftment of Allogeneic Bone Marrow in Major Histocompatibility Complex Mismatched Recipients Without Causing Graft-Versus-Host Disease" @default.
- W2229539623 cites W102290199 @default.
- W2229539623 cites W1497161431 @default.
- W2229539623 cites W1506034405 @default.
- W2229539623 cites W1564959198 @default.
- W2229539623 cites W1566450408 @default.
- W2229539623 cites W1585270289 @default.
- W2229539623 cites W1991537541 @default.
- W2229539623 cites W1993243592 @default.
- W2229539623 cites W2004212512 @default.
- W2229539623 cites W2016790166 @default.
- W2229539623 cites W201756653 @default.
- W2229539623 cites W2019964276 @default.
- W2229539623 cites W2032738293 @default.
- W2229539623 cites W2035622583 @default.
- W2229539623 cites W2069156127 @default.
- W2229539623 cites W2070665248 @default.
- W2229539623 cites W2071606276 @default.
- W2229539623 cites W2077522103 @default.
- W2229539623 cites W2080515775 @default.
- W2229539623 cites W2083102075 @default.
- W2229539623 cites W2088304714 @default.
- W2229539623 cites W2091783976 @default.
- W2229539623 cites W211697509 @default.
- W2229539623 cites W2164680537 @default.
- W2229539623 cites W2172700898 @default.
- W2229539623 cites W2222195888 @default.
- W2229539623 cites W2279123984 @default.
- W2229539623 cites W2394745099 @default.
- W2229539623 cites W2411127532 @default.
- W2229539623 cites W2413054781 @default.
- W2229539623 cites W2414835521 @default.
- W2229539623 cites W2418002416 @default.
- W2229539623 cites W261012566 @default.
- W2229539623 cites W2992138720 @default.
- W2229539623 cites W3021273376 @default.
- W2229539623 cites W311826078 @default.
- W2229539623 cites W312886274 @default.
- W2229539623 cites W4231354775 @default.
- W2229539623 cites W4232710580 @default.
- W2229539623 cites W4237002847 @default.
- W2229539623 cites W4246835761 @default.
- W2229539623 cites W4252030004 @default.
- W2229539623 cites W62199461 @default.
- W2229539623 cites W96052723 @default.
- W2229539623 doi "https://doi.org/10.1182/blood.v94.9.3222" @default.
- W2229539623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10556211" @default.
- W2229539623 hasPublicationYear "1999" @default.
- W2229539623 type Work @default.
- W2229539623 sameAs 2229539623 @default.
- W2229539623 citedByCount "60" @default.
- W2229539623 countsByYear W22295396232012 @default.
- W2229539623 countsByYear W22295396232013 @default.
- W2229539623 countsByYear W22295396232014 @default.
- W2229539623 countsByYear W22295396232015 @default.
- W2229539623 countsByYear W22295396232016 @default.
- W2229539623 countsByYear W22295396232017 @default.
- W2229539623 countsByYear W22295396232018 @default.
- W2229539623 countsByYear W22295396232019 @default.
- W2229539623 countsByYear W22295396232023 @default.
- W2229539623 crossrefType "journal-article" @default.
- W2229539623 hasAuthorship W2229539623A5011386306 @default.
- W2229539623 hasAuthorship W2229539623A5017056576 @default.
- W2229539623 hasAuthorship W2229539623A5023276777 @default.
- W2229539623 hasAuthorship W2229539623A5026075876 @default.
- W2229539623 hasAuthorship W2229539623A5027017698 @default.
- W2229539623 hasAuthorship W2229539623A5029572476 @default.
- W2229539623 hasAuthorship W2229539623A5053781658 @default.
- W2229539623 hasAuthorship W2229539623A5068525415 @default.
- W2229539623 hasAuthorship W2229539623A5089046175 @default.
- W2229539623 hasConcept C109159458 @default.
- W2229539623 hasConcept C126322002 @default.
- W2229539623 hasConcept C147483822 @default.
- W2229539623 hasConcept C188280979 @default.
- W2229539623 hasConcept C189976730 @default.
- W2229539623 hasConcept C202965653 @default.
- W2229539623 hasConcept C203014093 @default.
- W2229539623 hasConcept C207936829 @default.
- W2229539623 hasConcept C2776694085 @default.
- W2229539623 hasConcept C2776755627 @default.
- W2229539623 hasConcept C2778880498 @default.
- W2229539623 hasConcept C2779972918 @default.
- W2229539623 hasConcept C2780007613 @default.
- W2229539623 hasConcept C28328180 @default.
- W2229539623 hasConcept C2911091166 @default.