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- W2229599369 abstract "DCs often require stimulation from CD4(+) T cells to propagate CD8(+) T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why this appears to differ between varying types of CD8(+) T cell immunity remains unclear. We show that CD8(+) T cell priming upon HSV-1 skin infection depended on DCs receiving stimulation from both IFN-α/β and CD4(+) T cells to provide IL-15. This was not an additive effect but resulted from CD4(+) T cells amplifying DC production of IL-15 in response to IFN-α/β. We also observed that increased innate stimulation reversed the helper dependence of CD8(+) T cell priming and that the innate stimulus, rather than the CD4(+) T cells themselves, determined how help' was integrated into the priming response by DCs. These findings identify T cell help as a flexible means to amplify varying suboptimal innate signals in DCs." @default.
- W2229599369 created "2016-06-24" @default.
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- W2229599369 date "2016-01-01" @default.
- W2229599369 modified "2023-10-18" @default.
- W2229599369 title "T Cell Help Amplifies Innate Signals in CD8 + DCs for Optimal CD8 + T Cell Priming" @default.
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- W2229599369 doi "https://doi.org/10.1016/j.celrep.2015.12.058" @default.
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