FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2230191485> ?p ?o ?g. }

• W2230191485 abstract "Forskolin treatment of cells expressing Torpedo acetylcholine receptors leads to enhanced assembly efficiency of subunits, which correlates with increased phosphorylation of the gamma subunit. To determine the role of the two potential protein kinase A sites of the gamma subunit in receptor assembly, cell lines expressing different mutant receptors were established. Mouse fibroblast cell lines stably expressing wild-type Torpedo acetylcholine receptor alpha, beta, delta subunits plus one of three gamma subunit mutations (S353A, S354A, or S353,354A) were established to identify the protein kinase A phosphorylation sites of gamma in vivo, and to determine if increased phosphorylation of the gamma subunit leads to enhanced expression of receptors. We found that both serines (353, 354) in gamma are phosphorylated in vivo by protein kinase A, however, phosphorylation of either or both of these sites does not lead to increased assembly efficiency. We established a cell line expressing alpha, beta, and gamma(S353,354A) subunits only (no delta), and found that the presence of delta (or its phosphorylation) is also not necessary for the observed stimulation by forskolin. alpha beta gamma, alpha gamma, and beta gamma associations were stimulated by forskolin but alpha beta and alpha delta interactions were not. These data imply that the presence of gamma is necessary for forskolin action. We postulate that forskolin may stimulate acetylcholine receptor expression through a cellular protein that is involved in the folding and/or assembly of protein complexes, and that forskolin may regulate the action of such a protein through phosphorylation." @default.
• W2230191485 created "2016-06-24" @default.
• W2230191485 creator A5007701381 @default.
• W2230191485 creator A5011933507 @default.
• W2230191485 creator A5088277776 @default.
• W2230191485 date "1994-06-01" @default.
• W2230191485 modified "2023-09-26" @default.
• W2230191485 title "Cyclic AMP-regulated AChR assembly is independent of AChR subunit phosphorylation by PKA" @default.
• W2230191485 cites W1479982529 @default.
• W2230191485 cites W1487180725 @default.
• W2230191485 cites W150403848 @default.
• W2230191485 cites W1504266925 @default.
• W2230191485 cites W1521813923 @default.
• W2230191485 cites W1528493806 @default.
• W2230191485 cites W1533042261 @default.
• W2230191485 cites W1546450197 @default.
• W2230191485 cites W1570539079 @default.
• W2230191485 cites W1585703295 @default.
• W2230191485 cites W1638694981 @default.
• W2230191485 cites W1803379129 @default.
• W2230191485 cites W1947213606 @default.
• W2230191485 cites W1966763915 @default.
• W2230191485 cites W1968283219 @default.
• W2230191485 cites W1971290197 @default.
• W2230191485 cites W1972914774 @default.
• W2230191485 cites W1983460238 @default.
• W2230191485 cites W1983966699 @default.
• W2230191485 cites W1985944170 @default.
• W2230191485 cites W1987531495 @default.
• W2230191485 cites W1987872994 @default.
• W2230191485 cites W1990654868 @default.
• W2230191485 cites W1993870517 @default.
• W2230191485 cites W1996685233 @default.
• W2230191485 cites W2000758937 @default.
• W2230191485 cites W2001545350 @default.
• W2230191485 cites W2001578819 @default.
• W2230191485 cites W2004917770 @default.
• W2230191485 cites W2006663553 @default.
• W2230191485 cites W2008411984 @default.
• W2230191485 cites W2010691166 @default.
• W2230191485 cites W2012398870 @default.
• W2230191485 cites W2012473601 @default.
• W2230191485 cites W2018547231 @default.
• W2230191485 cites W2031377453 @default.
• W2230191485 cites W2035124140 @default.
• W2230191485 cites W2035177679 @default.
• W2230191485 cites W2036331500 @default.
• W2230191485 cites W2042869569 @default.
• W2230191485 cites W2044140136 @default.
• W2230191485 cites W2063213781 @default.
• W2230191485 cites W2066137693 @default.
• W2230191485 cites W2069733592 @default.
• W2230191485 cites W2070360831 @default.
• W2230191485 cites W2073151095 @default.
• W2230191485 cites W2076091117 @default.
• W2230191485 cites W2077135798 @default.
• W2230191485 cites W2085825273 @default.
• W2230191485 cites W2086532209 @default.
• W2230191485 cites W2087893167 @default.
• W2230191485 cites W2100087509 @default.
• W2230191485 cites W2100837269 @default.
• W2230191485 cites W2111266017 @default.
• W2230191485 cites W2111622916 @default.
• W2230191485 cites W2112320962 @default.
• W2230191485 cites W2115665711 @default.
• W2230191485 cites W2122345758 @default.
• W2230191485 cites W2124224385 @default.
• W2230191485 cites W2153151822 @default.
• W2230191485 cites W2159287109 @default.
• W2230191485 cites W2161576906 @default.
• W2230191485 cites W2164179462 @default.
• W2230191485 cites W2170945428 @default.
• W2230191485 cites W2176818920 @default.
• W2230191485 cites W2186496669 @default.
• W2230191485 cites W2199811320 @default.
• W2230191485 cites W2326326130 @default.
• W2230191485 cites W4233126096 @default.
• W2230191485 cites W4236380144 @default.
• W2230191485 doi "https://doi.org/10.1242/jcs.107.6.1641" @default.
• W2230191485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7962204" @default.
• W2230191485 hasPublicationYear "1994" @default.
• W2230191485 type Work @default.
• W2230191485 sameAs 2230191485 @default.
• W2230191485 citedByCount "4" @default.
• W2230191485 crossrefType "journal-article" @default.
• W2230191485 hasAuthorship W2230191485A5007701381 @default.
• W2230191485 hasAuthorship W2230191485A5011933507 @default.
• W2230191485 hasAuthorship W2230191485A5088277776 @default.
• W2230191485 hasConcept C104292427 @default.
• W2230191485 hasConcept C104317684 @default.
• W2230191485 hasConcept C11960822 @default.
• W2230191485 hasConcept C123419017 @default.
• W2230191485 hasConcept C153911025 @default.
• W2230191485 hasConcept C170493617 @default.
• W2230191485 hasConcept C2779276759 @default.
• W2230191485 hasConcept C2910882050 @default.
• W2230191485 hasConcept C55493867 @default.
• W2230191485 hasConcept C80161118 @default.
• W2230191485 hasConcept C83730767 @default.
• W2230191485 hasConcept C86803240 @default.

• next