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- W2230309072 abstract "Alcoholic liver disease (ALD) spans a spectrum of liver pathology, including fatty liver, alcoholic steatohepatitis, and cirrhosis. Accumulating evidence suggests that dietary factors, including dietary fat, as well as alcohol, play critical roles in the pathogenesis of ALD. The protective effects of dietary saturated fat (SF) and deleterious effects of dietary unsaturated fat (USF) on alcohol-induced liver pathology are well recognized and documented in experimental animal models of ALD. Moreover, it has been demonstrated in an epidemiological study of alcoholic cirrhosis that dietary intake of SF was associated with a lower mortality rates, whereas dietary intake of USF was associated with a higher mortality. In addition, oxidized lipids (dietary and in vivo generated) may play a role in liver pathology. The understanding of how dietary fat contributes to the ALD pathogenesis will enhance our knowledge regarding the molecular mechanisms of ALD development and progression, and may result in the development of novel diet-based therapeutic strategies for ALD management. This review explores the relevant scientific literature and provides a current understanding of recent advances regarding the role of dietary lipids in ALD pathogenesis." @default.
- W2230309072 created "2016-06-24" @default.
- W2230309072 creator A5012100988 @default.
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- W2230309072 creator A5027897501 @default.
- W2230309072 creator A5055645984 @default.
- W2230309072 creator A5083426937 @default.
- W2230309072 date "2016-01-06" @default.
- W2230309072 modified "2023-10-14" @default.
- W2230309072 title "Alcoholic Liver Disease: Update on the Role of Dietary Fat" @default.
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