Matches in SemOpenAlex for { <https://semopenalex.org/work/W2230341044> ?p ?o ?g. }
- W2230341044 endingPage "1082" @default.
- W2230341044 startingPage "1070" @default.
- W2230341044 abstract "Zinc is a trace element important for synaptic plasticity, learning and memory. Zinc deficiency, both during pregnancy and after birth, impairs cognitive performance and, in addition to memory deficits, also results in alterations of attention, activity, neuropsychological behavior and motor development. The effects of zinc supplementation on cognition, particularly in the adult, are less clear. We demonstrate here in adult rats, that 4 week-long zinc supplementation given by drinking water, and approximately doubling normal daily intake, strongly impairs consolidation of hippocampal-dependent memory, tested through contextual fear conditioning and inhibitory avoidance. Furthermore, the same treatment started after memory consolidation of training for the same behavioral tests, substantially dampens the recall of the stressful event occurred 4 weeks before. A molecular correlate of the amnesic effect of zinc supplementation is represented by a dysregulated function of GSK-3ß in the hippocampus, a kinase that participates in memory processes. The possible relevance of these data for humans, in particular regarding post-traumatic stress disorders, is discussed in view of future investigation." @default.
- W2230341044 created "2016-06-24" @default.
- W2230341044 creator A5013871124 @default.
- W2230341044 creator A5083179290 @default.
- W2230341044 creator A5088766968 @default.
- W2230341044 creator A5090475908 @default.
- W2230341044 date "2016-06-01" @default.
- W2230341044 modified "2023-09-26" @default.
- W2230341044 title "Zinc supplementation in rats impairs hippocampal-dependent memory consolidation and dampens post-traumatic recollection of stressful event" @default.
- W2230341044 cites W10673897 @default.
- W2230341044 cites W1178553251 @default.
- W2230341044 cites W1584535802 @default.
- W2230341044 cites W1758789982 @default.
- W2230341044 cites W1775749144 @default.
- W2230341044 cites W1937980604 @default.
- W2230341044 cites W1946757792 @default.
- W2230341044 cites W1953359380 @default.
- W2230341044 cites W1956983065 @default.
- W2230341044 cites W1960647274 @default.
- W2230341044 cites W1964597381 @default.
- W2230341044 cites W1964772923 @default.
- W2230341044 cites W1970000810 @default.
- W2230341044 cites W1972614641 @default.
- W2230341044 cites W1973115255 @default.
- W2230341044 cites W1973528773 @default.
- W2230341044 cites W1973563491 @default.
- W2230341044 cites W1974341617 @default.
- W2230341044 cites W1976648812 @default.
- W2230341044 cites W1978054272 @default.
- W2230341044 cites W1982961937 @default.
- W2230341044 cites W1983311824 @default.
- W2230341044 cites W1984513006 @default.
- W2230341044 cites W1988226054 @default.
- W2230341044 cites W1991889108 @default.
- W2230341044 cites W1994346896 @default.
- W2230341044 cites W1996515510 @default.
- W2230341044 cites W1998157180 @default.
- W2230341044 cites W1998574433 @default.
- W2230341044 cites W1999821982 @default.
- W2230341044 cites W2002358056 @default.
- W2230341044 cites W2008980341 @default.
- W2230341044 cites W2015511959 @default.
- W2230341044 cites W2020682145 @default.
- W2230341044 cites W2029712849 @default.
- W2230341044 cites W2035089473 @default.
- W2230341044 cites W2041341129 @default.
- W2230341044 cites W2043423644 @default.
- W2230341044 cites W2054566340 @default.
- W2230341044 cites W2058459224 @default.
- W2230341044 cites W2059856205 @default.
- W2230341044 cites W2060893933 @default.
- W2230341044 cites W2062741447 @default.
- W2230341044 cites W2066118643 @default.
- W2230341044 cites W2070794162 @default.
- W2230341044 cites W2070802660 @default.
- W2230341044 cites W2070972798 @default.
- W2230341044 cites W2074657485 @default.
- W2230341044 cites W2078710059 @default.
- W2230341044 cites W2110652761 @default.
- W2230341044 cites W2114736131 @default.
- W2230341044 cites W2115270413 @default.
- W2230341044 cites W2116858555 @default.
- W2230341044 cites W2118775306 @default.
- W2230341044 cites W2144397723 @default.
- W2230341044 cites W2144507143 @default.
- W2230341044 cites W2145884075 @default.
- W2230341044 cites W2162861984 @default.
- W2230341044 cites W2334140913 @default.
- W2230341044 doi "https://doi.org/10.1016/j.euroneuro.2015.12.041" @default.
- W2230341044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26774280" @default.
- W2230341044 hasPublicationYear "2016" @default.
- W2230341044 type Work @default.
- W2230341044 sameAs 2230341044 @default.
- W2230341044 citedByCount "11" @default.
- W2230341044 countsByYear W22303410442016 @default.
- W2230341044 countsByYear W22303410442017 @default.
- W2230341044 countsByYear W22303410442018 @default.
- W2230341044 countsByYear W22303410442019 @default.
- W2230341044 countsByYear W22303410442020 @default.
- W2230341044 countsByYear W22303410442021 @default.
- W2230341044 crossrefType "journal-article" @default.
- W2230341044 hasAuthorship W2230341044A5013871124 @default.
- W2230341044 hasAuthorship W2230341044A5083179290 @default.
- W2230341044 hasAuthorship W2230341044A5088766968 @default.
- W2230341044 hasAuthorship W2230341044A5090475908 @default.
- W2230341044 hasConcept C100660578 @default.
- W2230341044 hasConcept C126322002 @default.
- W2230341044 hasConcept C138496976 @default.
- W2230341044 hasConcept C148762608 @default.
- W2230341044 hasConcept C15744967 @default.
- W2230341044 hasConcept C169760540 @default.
- W2230341044 hasConcept C169900460 @default.
- W2230341044 hasConcept C170493617 @default.
- W2230341044 hasConcept C180747234 @default.
- W2230341044 hasConcept C2277912 @default.
- W2230341044 hasConcept C2781161787 @default.
- W2230341044 hasConcept C48455012 @default.
- W2230341044 hasConcept C71924100 @default.