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• W2230346364 abstract "Needle biopsies taken from renal allografts of 42 renal transplant patients were tested for in vitro propagation of graft-infiltrating T-lymphocytes (GITL). From 30 out of 42 needle biopsies T-lymphocyte cell lines could be established. There was a significant correlation between in vitro outgrowth of T cells and histological signs of graft rejection. The majority of GITL cell lines displayed cytotoxicity both against donor proximal tubular epithelial cells (PTEC) and PHA stimulated donor splenocytes in an MHC class I restricted fashion. However, six cell lines were only cytotoxic against donor PTEC which is suggestive of recognition of tissue-specific antigens by these GITL derived T-cell lines. Analysis to the level of diversity of the T-cell receptor repertoire by PCR with TCRBV-family specific-oligonucleotides of a selection of these GITL derived cell lines revealed that the majority of the T-cell lines tested were polyclonal in nature on the basis of TCRBV gene family usage. A clear dominance of TCRBV genes was observed in only three GITL derived T-cell lines. There was no apparent correlation with the diversity of the TCRBV repertoire of GITL derived T-cell lines and the number of HLA-mismatches between the recipient and donor derived graft. Furthermore, the time interval between the transplantation and biopsy sampling did not contribute to the level of diversity of the TCRBV repertoire nor the tissue-specificity of these GITL derived T-cell lines." @default.
• W2230346364 created "2016-06-24" @default.
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• W2230346364 date "1995-01-01" @default.
• W2230346364 modified "2023-09-27" @default.
• W2230346364 title "T-Cell Receptor V-Gene Usage in T-Cell Lines Propogated from Graft-Infiltrating T Lymphocytes in Needle Biopsies of Rejecting Renal Allografts" @default.
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• W2230346364 doi "https://doi.org/10.1007/978-3-662-22494-6_5" @default.
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