FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2230347324> ?p ?o ?g. }

• W2230347324 abstract "7051 Background: AML is a heterogeneous group of hematopoietic neoplasms demonstrating clonal proliferation of myeloid precursors and is typically a disease of older adults. Little is known about outcomes of AYA with AML. Methods: We retrospectively analyzed all patients (pts) with AML treated at MDACC from 1965 to 2008. Pts ages 16 to 21 years (yrs) were defined as AYA. Results: Among 3,934 adult AML pts treated during this period, 163 pts (4%) were AYA with median age of 19 yrs. This cohort included 27 (17%) pts with Core Binding Factor (CBF)-AML [inv(16), t(8:21)] and 19 pts (12%) with acute promyelocytic leukemia (APL). Among the other pts, 50% had diploid cytogenetics, 11% had 5 or 7 abnormalities, 39% had other cytogenetic changes. Antecedent hematologic disorders were present in 33 pts (20%). Among 20 evaluated pts, FLT3 internal tandem duplication (ITD) was present in 4 pts and FLT3 kinase domain mutation was found in 2 pts. Complete remission (CR) rates were 89% for CBF AML, 79% for APL, and 75% for all other pts. Median survival for the total cohort was 1.7 yrs with 36% alive at 3 yrs, and median CR duration of 1.3 yrs (30% CR at 3 yrs). Outcome is better for pts with CBF leukemia (3 yr survival 56%, sustained CR 49%) and APL (3 yr survival 51%, sustained CR 36%) compared to other AML (3 yr survival 28%, sustained CR 24%). CR rates have improved from 71% in 1965–1984, to 85% in 1985–1994, and 83% after 1994. Similarly, overall survival (OS) has increased during the same time periods (3-yr survival 18%, 44%, and 53%, respectively) together with CR duration (3 yr CR duration 21%, 32% and 39%, respectively) as early mortality has decreased (11%, 8%, and 4%, respectively). To compare outcomes of AYA with older adults, we focused on those with diploid cytogenetics.CR for pts ages 16–21 was 81%, with 3 yr survival of 46%; for ages 22–45, CR was 75% and 3 yr survival 36%; for ages 46–60 CR was 68% with 3 yr survival 28%; and for pts age greater than 60, CR was 54% with 3 yr survival of 22%. Conclusions: The outcome of AYA pts with AML is significantly better than for older adults with AML. Despite the advances in treatments over time, there is still significant room for improvement, particularly among those AYA with AML other than CBF and APL. Exploration of new treatment options is needed in this patient population. No significant financial relationships to disclose." @default.
• W2230347324 created "2016-06-24" @default.
• W2230347324 creator A5000750846 @default.
• W2230347324 creator A5006104041 @default.
• W2230347324 creator A5015101485 @default.
• W2230347324 creator A5030500582 @default.
• W2230347324 creator A5038307470 @default.
• W2230347324 creator A5055045706 @default.
• W2230347324 creator A5061026876 @default.
• W2230347324 creator A5088307376 @default.
• W2230347324 creator A5089428686 @default.
• W2230347324 creator A5090435894 @default.
• W2230347324 date "2009-05-20" @default.
• W2230347324 modified "2023-10-15" @default.
• W2230347324 title "Acute myeloid leukemia (AML) in adolescents and young adults (AYA): The M. D. Anderson Cancer Center (MDACC) experience" @default.
• W2230347324 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.7051" @default.
• W2230347324 hasPublicationYear "2009" @default.
• W2230347324 type Work @default.
• W2230347324 sameAs 2230347324 @default.
• W2230347324 citedByCount "1" @default.
• W2230347324 countsByYear W22303473242012 @default.
• W2230347324 crossrefType "journal-article" @default.
• W2230347324 hasAuthorship W2230347324A5000750846 @default.
• W2230347324 hasAuthorship W2230347324A5006104041 @default.
• W2230347324 hasAuthorship W2230347324A5015101485 @default.
• W2230347324 hasAuthorship W2230347324A5030500582 @default.
• W2230347324 hasAuthorship W2230347324A5038307470 @default.
• W2230347324 hasAuthorship W2230347324A5055045706 @default.
• W2230347324 hasAuthorship W2230347324A5061026876 @default.
• W2230347324 hasAuthorship W2230347324A5088307376 @default.
• W2230347324 hasAuthorship W2230347324A5089428686 @default.
• W2230347324 hasAuthorship W2230347324A5090435894 @default.
• W2230347324 hasConcept C121608353 @default.
• W2230347324 hasConcept C126322002 @default.
• W2230347324 hasConcept C143998085 @default.
• W2230347324 hasConcept C185592680 @default.
• W2230347324 hasConcept C205545832 @default.
• W2230347324 hasConcept C2778461978 @default.
• W2230347324 hasConcept C2778729363 @default.
• W2230347324 hasConcept C2779463800 @default.
• W2230347324 hasConcept C71924100 @default.
• W2230347324 hasConcept C74909509 @default.
• W2230347324 hasConcept C8010536 @default.
• W2230347324 hasConceptScore W2230347324C121608353 @default.
• W2230347324 hasConceptScore W2230347324C126322002 @default.
• W2230347324 hasConceptScore W2230347324C143998085 @default.
• W2230347324 hasConceptScore W2230347324C185592680 @default.
• W2230347324 hasConceptScore W2230347324C205545832 @default.
• W2230347324 hasConceptScore W2230347324C2778461978 @default.
• W2230347324 hasConceptScore W2230347324C2778729363 @default.
• W2230347324 hasConceptScore W2230347324C2779463800 @default.
• W2230347324 hasConceptScore W2230347324C71924100 @default.
• W2230347324 hasConceptScore W2230347324C74909509 @default.
• W2230347324 hasConceptScore W2230347324C8010536 @default.
• W2230347324 hasLocation W22303473241 @default.
• W2230347324 hasOpenAccess W2230347324 @default.
• W2230347324 hasPrimaryLocation W22303473241 @default.
• W2230347324 hasRelatedWork W1499203393 @default.
• W2230347324 hasRelatedWork W2028896773 @default.
• W2230347324 hasRelatedWork W2043614076 @default.
• W2230347324 hasRelatedWork W2078934291 @default.
• W2230347324 hasRelatedWork W2084561785 @default.
• W2230347324 hasRelatedWork W2114266573 @default.
• W2230347324 hasRelatedWork W2267190567 @default.
• W2230347324 hasRelatedWork W2327960555 @default.
• W2230347324 hasRelatedWork W2423837600 @default.
• W2230347324 hasRelatedWork W2430117454 @default.
• W2230347324 hasRelatedWork W2482748337 @default.
• W2230347324 hasRelatedWork W2599781422 @default.
• W2230347324 hasRelatedWork W2605060585 @default.
• W2230347324 hasRelatedWork W2811382010 @default.
• W2230347324 hasRelatedWork W2935733937 @default.
• W2230347324 hasRelatedWork W2946439170 @default.
• W2230347324 hasRelatedWork W2967905549 @default.
• W2230347324 hasRelatedWork W3028714401 @default.
• W2230347324 hasRelatedWork W2337314844 @default.
• W2230347324 hasRelatedWork W2529069211 @default.
• W2230347324 isParatext "false" @default.
• W2230347324 isRetracted "false" @default.
• W2230347324 magId "2230347324" @default.
• W2230347324 workType "article" @default.