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• W2230464055 abstract "Abstract We accumulated mutations for 1952 generations in 79 initially identical, haploid lines of the fission yeast Schizosaccharomyces pombe, and then performed whole-genome sequencing to determine the mutation rates and spectrum. We captured 696 spontaneous mutations across the 79 mutation accumulation (MA) lines. We compared the mutation spectrum and rate to a recently published equivalent experiment on the same species, and to another model ascomycetous yeast, the budding yeast Saccharomyces cerevisiae. While the two species are approximately 600 million years diverged from each other, they share similar life histories, genome size and genomic G/C content. We found that Sc. pombe and S. cerevisiae have similar mutation rates, but Sc. pombe exhibits a stronger insertion bias. Intriguingly, we observed an increased mutation rate at cytosine nucleotides, specifically CpG nucleotides, which is also seen in S. cerevisiae. However, the absence of methylation in Sc. pombe and the pattern of mutation at these sites, primarily C → A as opposed to C → T, strongly suggest that the increased mutation rate is not caused by deamination of methylated cytosines. This result implies that the high mutability of CpG dinucleotides in other species may be caused in part by a methylation-independent mechanism. Many of our findings mirror those seen in the recent study, despite the use of different passaging conditions, indicating that MA is a reliable method for estimating mutation rates and spectra." @default.
• W2230464055 created "2016-06-24" @default.
• W2230464055 creator A5027309077 @default.
• W2230464055 creator A5048410492 @default.
• W2230464055 date "2016-01-01" @default.
• W2230464055 modified "2023-10-13" @default.
• W2230464055 title "Genome-Wide Estimates of Mutation Rates and Spectrum in<i>Schizosaccharomyces pombe</i>Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation" @default.
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• W2230464055 cites W1485011392 @default.
• W2230464055 cites W1499500424 @default.
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• W2230464055 cites W1827569717 @default.
• W2230464055 cites W1861303592 @default.
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• W2230464055 cites W1870447056 @default.
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• W2230464055 cites W1965561195 @default.
• W2230464055 cites W1967609937 @default.
• W2230464055 cites W1973175445 @default.
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• W2230464055 cites W2021326398 @default.
• W2230464055 cites W2021341670 @default.
• W2230464055 cites W2023723397 @default.
• W2230464055 cites W2029034653 @default.
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• W2230464055 cites W2041902801 @default.
• W2230464055 cites W2041922986 @default.
• W2230464055 cites W2046233233 @default.
• W2230464055 cites W2046255935 @default.
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• W2230464055 cites W2055595349 @default.
• W2230464055 cites W2059383371 @default.
• W2230464055 cites W2059661893 @default.
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• W2230464055 cites W2073365346 @default.
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• W2230464055 cites W2079121387 @default.
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• W2230464055 cites W2096630319 @default.
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• W2230464055 cites W2099540110 @default.
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• W2230464055 cites W2104570606 @default.
• W2230464055 cites W2115367924 @default.
• W2230464055 cites W2116402707 @default.
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• W2230464055 doi "https://doi.org/10.1534/g3.115.022129" @default.
• W2230464055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704713" @default.
• W2230464055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26564949" @default.
• W2230464055 hasPublicationYear "2016" @default.
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