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• W2230748303 endingPage "102" @default.
• W2230748303 startingPage "79" @default.
• W2230748303 abstract "The vertebrate retina has many features that make it an outstanding model for studying both neuronal coupling and glial coupling in the central nervous system (CNS).1 The neural retina forms a transparent sheet, about 100 gm thick, which lines the back of the vitreous chamber, and the retina’s only link with the brain is provided by the optic nerve, which carries the axons of the retinal ganglion cells. Consequently, the intact retina can be readily isolated both from the rest of the CNS (eyecup preparations) and, if need be, from the underlying pigment epithelium and sclera (wholemount preparations). The retina has thus been described as “nature’s brain slice” and the ability to preserve the structural integrity of the retina in vitro is a critical feature of this model system, particularly given the mounting evidence that tissue sectioning reduces neuronal coupling in both the brain2 and the retina.3 The isolated retina thus retains many of the important advantages of in vivo preparations (intact neuronal circuitry; responsiveness to natural stimuli), while gaining the significant benefits of in vitro preparations (recording stability; microscopic identification of cells; controlled application of drugs)." @default.
• W2230748303 created "2016-06-24" @default.
• W2230748303 creator A5023747665 @default.
• W2230748303 date "1996-01-01" @default.
• W2230748303 modified "2023-10-13" @default.
• W2230748303 title "Cell Coupling in the Retina" @default.
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