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- W2230768109 abstract "20561 Background: Race, gender, gene expression, and age have all been reported to affect the risk of regimen-related toxicities. Although the risk could vary across geographic differences, this factor has not been studied. Aim of this study was to compare the frequencies of regimen-related acute toxicities between American and Italian CRC patients. Methods: Electronic medical charts of 503 patients treated with oxaliplatin, irinotecan, and/or 5-Fluorouracil based regimens were reviewed. The populations were matched for median age, sex, race, and stage of disease. Baseline demographics, clinical information, and overall incidence of treatment-related NCI-CTC toxicities reported during the first two cycles of chemotherapy were recorded. We selected for comparison only toxicities with a reported frequency of at least 10% in the original American cohort. Chi-square test was used for comparison. Results: The overall incidence of gastrointestinal and constitutional toxicities was more in the American cohort, while Italian patients experienced an higher rate of pain and sensory neuropathy, probably due to an higher oxaliplatin exposition (67 versus 49%). Most of the observed differences were confined to grade 1 toxicities Conclusions: In general, compared to American CRC patients, Italian patients experience less acute toxicity following cycle 1 and cycle 2 chemotherapy Toxicity (any grade) US pts, cy 1 (n=300), % Italian pts, cy 1 (n=203), % p value US pts, cy 2 (n=297), % Italian pts, cy 2 (n=203), % p value dyspepsia 10,0 7,5 p=0.361 22.6 11.3 p=0.004 dehydration 10,7 4,5 p=0.016 13.8 3.9 p=0.001 palpitation 11,7 5 p=0.014 11.8 4.4 p=0.007 fever 14,0 6,5 p=0.013 16.5 8.9 p=0.022 bloating 16,7 7 p<0.001 21.9 9.9 p=0.001 pain 17,7 21 p=0.402 17.2 26.6 p=0.024 vomiting 21,7 11 p<0.001 25.3 10.8 P<0.001 sensory neuropathy 22,3 32 p=0.038 28.3 44.8 p=0.002 mucositis 24,7 22,5 p=0.953 45.8 28.1 p=0.003 anorexia 25,0 7,5 p<0.001 32.3 12.3 p<0.001 diarrhea 50,0 24.5 p<0.001 66.0 22.7 p<0.001 asthenia/fatigue 55,3 46,5 p=0.179 73.7 54.7 p=0.01 nausea 56,7 37,5 p<0.001 68.0 37.0 p<0.001 No significant financial relationships to disclose." @default.
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- W2230768109 date "2008-05-20" @default.
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- W2230768109 title "Geographical differences in acute treatment-related toxicity frequencies: A comparative analysis of 503 colorectal cancer (CRC) patients receiving chemotherapy" @default.
- W2230768109 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.20561" @default.
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