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• W2230804596 abstract "The posterior cingulate cortex (PCC) is an important brain connectivity network hub which is particularly sensitive to AD. This heterogeneous structure can be subdivided into ventral (vPCC) and dorsal (dPCC) regions that showed distinct connectivity. The aim of the present work was to highlight functional connectivity (FC) disruption, atrophy, and hypometabolism within the vPCC and dPCC networks in patients with amnestic Mild Cognitive Impairment (aMCI) and AD. Forty-three healthy elderly (HE) (68.7 ± 6 years), 34 aMCI (73.4 ± 6.8) and 24 AD (70.9 ± 9.1) patients underwent resting-state functional MRI, FDG-PET and anatomical T1-weighted MRI. FC maps from the vPCC and dPCC were obtained, and compared to identify the ventral and dorsal networks. Functional connectivity, gray matter volume and metabolism within each network were then compared between groups. In HE, the ventral network included the hippocampus and temporo-parietal regions, whereas the dorsal network involved the precuneus, supramarginal, anterior temporal and dorso-medial prefrontal regions. aMCi patients had impaired ventral network FC in the bilateral hippocampus while the dorsal network FC was preserved. . In AD, the ventral network FC disruption spread into the left parahippocampal and angular regions and the dorsal network FC was also affected in the right inferior middle temporal region. The ventral network was atrophied in bilateral hippocampus in aMCI and in the vPCC and angular regions as well in AD. The dorsal network was only atrophied in AD in the dPCC, bilateral supramarginal and temporal regions. By contrast, hypometabolism was already present in both the vPCC and the dPCC networks in aMCI patients and further extended to include the whole networks in patients with AD. The vPCC and dPCC connectivity networks are differentially sensitive to AD. In the vPCC network, FC disruption, atrophy and hypometabolism occur early (in aMCI patients) and amplify in AD. By contrast, the dPCC network is only hypometabolic in the aMCI stage and becomes atrophic and FC disrupted in AD. This suggests that atrophy and FC disruption spread from the ventral to the dorsal PCC networks while hypometabolism is not constrained by these networks. Differential functional disruption (A), atrophy (B) and hypometabolism (C) between ventral and dorsal posterior cingulate cortex (PCC) networks in Mild Cognitive Impairment and Alzheimer disease. The ventral PCC network is in purple and the dorsal PCC network is in blue. For the three modalities, disruptions in the ventral PCC network are shown in red and disruptions in the dorsal PCC network are shown in green." @default.
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• W2230804596 date "2015-07-01" @default.
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• W2230804596 title "O3-09-01: Differential functional disruption, hypometabolism, and atrophy between ventral and dorsal posterior cingulate cortex networks in mild cognitive impairment and Alzheimer's disease" @default.
• W2230804596 doi "https://doi.org/10.1016/j.jalz.2015.07.285" @default.
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