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- W2230820003 abstract "Abstract State and function of the histidine residues of aminoacylase were investigated by photooxidation in the presence of methylene blue and by chemical modification with diethylpyrocarbonate. Complete inactivation of the enzyme was observed after oxidation of 4 histidine residues. From the pH dependence of the photooxidation it becomes evident that the inactivation of the enzyme is not a consequence of the simultaneous oxidation of tryptophan residues. The enzyme is also inctivated by chemical modification of histidine residues with diethylpyrocarbonate. Activity is restored by treatment with hydroxylamine. Zn 2+ -ions which are essential for the activity of amino acylase protect the available histidine molecules against photooxidation and attack by diethyl pyrocarbonate. It is suggested that histidine is involved in the binding of the essential Zn 2+ -ions." @default.
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- W2230820003 date "1977-06-01" @default.
- W2230820003 modified "2023-09-24" @default.
- W2230820003 title "Identification of Essential Histidine Residues of Aminoacylase by Photooxidation and by Reaction with Diethylpyrocarbonate" @default.
- W2230820003 doi "https://doi.org/10.1515/znc-1977-5-604" @default.
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