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• W2230834630 endingPage "H1607" @default.
• W2230834630 startingPage "H1599" @default.
• W2230834630 abstract "The aim of the present study was to assess differences in transient outward potassium current ( I to ) between the right ventricular free wall and the interventricular septum of the adult rat ventricle and to evaluate the relative contributions of Kv4.2, Kv4.3, and Kv1.4 to I to in these regions. The results show that I to is composed of both rapidly and slowly recovering components in the right wall and septum. The fast component had a significantly higher density in the right free wall than in the septum, whereas the slow component did not differ between the two sites. Kv4.2mRNA and protein levels were also highest in the right wall and correlated with I to density, whereas Kv4.3 was expressed uniformly in these regions. The kinetics of the rapidly recovering component of I to in myocytes was similar to that recorded in tsa-201 cells expressing Kv4.2 and Kv4.3 channels. Kv1.4 mRNA and protein expression correlated well with the density of the slowly recovering I to , whereas the recovery kinetics of the slow component were identical to Kv1.4 expressed in tsa-201 cells. In conclusion, expression of Kv1.4, Kv4.2, and Kv4.3 differs between regions in rat hearts. Regionally specific differences in the genetic composition of I to can account for the region-specific properties of this current." @default.
• W2230834630 created "2016-06-24" @default.
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• W2230834630 date "1999-05-01" @default.
• W2230834630 modified "2023-10-16" @default.
• W2230834630 title "Regional contributions of<i>Kv1.4</i>,<i>Kv4.2</i>, and<i>Kv4.3</i>to transient outward K⁺current in rat ventricle" @default.
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• W2230834630 doi "https://doi.org/10.1152/ajpheart.1999.276.5.h1599" @default.
• W2230834630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10330244" @default.
• W2230834630 hasPublicationYear "1999" @default.
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