Matches in SemOpenAlex for { <https://semopenalex.org/work/W2230897110> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2230897110 endingPage "4" @default.
- W2230897110 startingPage "1762" @default.
- W2230897110 abstract "To examine the ability of rofecoxib prophylaxis to blunt the effect of monosodium urate (MSU) crystal inflammation induced in the rat subcutaneous air pouch.Eight rats were used in each of 4 groups. On day one, air was injected subcutaneously to create the pouches and gavage feedings were started with placebo or 2 different doses of rofecoxib. Six days later MSU crystals or saline were injected into the pouches. Twenty-four hours later, rats were examined, sacrificed, and pouch fluid studied.Rofecoxib 15 or 30 mg/kg given for 6 days before MSU crystal injection into rat air pouches significantly suppressed the inflammation following injection of 10 mg crystals (p = 0.001) and tended to suppress the milder inflammation induced by 5 mg MSU. Greater effects on phagocytosis were seen with 30 mg/kg rofecoxib. Tumor necrosis factor-alpha levels in pouch fluid measured by ELISA were not suppressed by the rofecoxib.Prophylactic use of this cyclooxygenase 2 (COX-2) selective inhibitor in this pilot study suppressed acute MSU crystal induced inflammation. Effects on cytokines need further investigation. COX-2 inhibitors deserve consideration for prophylactic use in interim gout." @default.
- W2230897110 created "2016-06-24" @default.
- W2230897110 creator A5023619887 @default.
- W2230897110 creator A5025346132 @default.
- W2230897110 creator A5066565534 @default.
- W2230897110 creator A5076416788 @default.
- W2230897110 creator A5037122682 @default.
- W2230897110 date "2005-09-01" @default.
- W2230897110 modified "2023-09-26" @default.
- W2230897110 title "Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch." @default.
- W2230897110 cites W1979670706 @default.
- W2230897110 cites W1981592867 @default.
- W2230897110 cites W1993933731 @default.
- W2230897110 cites W2007434222 @default.
- W2230897110 cites W202378911 @default.
- W2230897110 cites W2042542426 @default.
- W2230897110 cites W2065001772 @default.
- W2230897110 cites W2124187588 @default.
- W2230897110 cites W2137981468 @default.
- W2230897110 cites W2215586036 @default.
- W2230897110 cites W2300407945 @default.
- W2230897110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16142876" @default.
- W2230897110 hasPublicationYear "2005" @default.
- W2230897110 type Work @default.
- W2230897110 sameAs 2230897110 @default.
- W2230897110 citedByCount "5" @default.
- W2230897110 crossrefType "journal-article" @default.
- W2230897110 hasAuthorship W2230897110A5023619887 @default.
- W2230897110 hasAuthorship W2230897110A5025346132 @default.
- W2230897110 hasAuthorship W2230897110A5037122682 @default.
- W2230897110 hasAuthorship W2230897110A5066565534 @default.
- W2230897110 hasAuthorship W2230897110A5076416788 @default.
- W2230897110 hasConcept C126322002 @default.
- W2230897110 hasConcept C134018914 @default.
- W2230897110 hasConcept C141071460 @default.
- W2230897110 hasConcept C181199279 @default.
- W2230897110 hasConcept C185592680 @default.
- W2230897110 hasConcept C2776390293 @default.
- W2230897110 hasConcept C2776914184 @default.
- W2230897110 hasConcept C2778582115 @default.
- W2230897110 hasConcept C2779689624 @default.
- W2230897110 hasConcept C2780101441 @default.
- W2230897110 hasConcept C2780402116 @default.
- W2230897110 hasConcept C55493867 @default.
- W2230897110 hasConcept C71924100 @default.
- W2230897110 hasConcept C98274493 @default.
- W2230897110 hasConceptScore W2230897110C126322002 @default.
- W2230897110 hasConceptScore W2230897110C134018914 @default.
- W2230897110 hasConceptScore W2230897110C141071460 @default.
- W2230897110 hasConceptScore W2230897110C181199279 @default.
- W2230897110 hasConceptScore W2230897110C185592680 @default.
- W2230897110 hasConceptScore W2230897110C2776390293 @default.
- W2230897110 hasConceptScore W2230897110C2776914184 @default.
- W2230897110 hasConceptScore W2230897110C2778582115 @default.
- W2230897110 hasConceptScore W2230897110C2779689624 @default.
- W2230897110 hasConceptScore W2230897110C2780101441 @default.
- W2230897110 hasConceptScore W2230897110C2780402116 @default.
- W2230897110 hasConceptScore W2230897110C55493867 @default.
- W2230897110 hasConceptScore W2230897110C71924100 @default.
- W2230897110 hasConceptScore W2230897110C98274493 @default.
- W2230897110 hasIssue "9" @default.
- W2230897110 hasLocation W22308971101 @default.
- W2230897110 hasOpenAccess W2230897110 @default.
- W2230897110 hasPrimaryLocation W22308971101 @default.
- W2230897110 hasRelatedWork W1537277145 @default.
- W2230897110 hasRelatedWork W2009683787 @default.
- W2230897110 hasRelatedWork W2020033336 @default.
- W2230897110 hasRelatedWork W2072592383 @default.
- W2230897110 hasRelatedWork W2088107344 @default.
- W2230897110 hasRelatedWork W2095747615 @default.
- W2230897110 hasRelatedWork W2140040700 @default.
- W2230897110 hasRelatedWork W2165707196 @default.
- W2230897110 hasRelatedWork W2230897110 @default.
- W2230897110 hasRelatedWork W3030179015 @default.
- W2230897110 hasVolume "32" @default.
- W2230897110 isParatext "false" @default.
- W2230897110 isRetracted "false" @default.
- W2230897110 magId "2230897110" @default.
- W2230897110 workType "article" @default.