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- W2230915957 abstract "AACR Annual Meeting-- Apr 18-22, 2009; Denver, CORats are shown to be more susceptible to the development of mammary carcinomas when they are exposed to DMBA, during the 30-50 day-old (pubertal) period. By contrast, rats when exposed to genistein, during the early stages of mammary development (prenatal, neonatal, or pre-pubertal periods), have a reduced risk of chemical-induced mammary cancer. In the present study, we show that the abundance and activity of TCA cycle enzymes such as succinate dehydrogenase-B, fumarase and NAD+ isocitrate dehydrogenase in the mammary gland of Sprague-Dawley rats are significantly lower during puberty (day 50) compared to the prepubertal (day 21) period. Moreover, there was a subsequent activation of HIF-1#945; in the epithelial cells of mammary gland during pubertal period. On the contrary, the abundance of these enzymes was significantly higher in resveratrol and genistein treated rats on day 50 and day 21 than the untreated control animals. These results indicate that, during puberty, the mammary gland microenvironment exists in a #8220;pseudo-hypoxic#8221; condition, which may potentially make it more vulnerable to tumor initiation by carcinogens. Restoration of TCA cycle enzyme levels and subsequent biochemical changes in the mammary gland may be one of the mechanisms by which dietary polyphenols reduce the risk of chemical-induced mammary cancer. Further studies will help to develop new approaches to breast cancer prevention, timely implementation of prevention strategies successfully in high-risk groups, and elucidate the mechanism of mammary carcinogenesis.Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 13." @default.
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- W2230915957 date "2009-05-01" @default.
- W2230915957 modified "2023-09-26" @default.
- W2230915957 title "Abstract #13: Decreased expression of TCA cycle enzymes and HIF-1#945; activation in the developing mammary gland_potential role in the higher susceptibility to carcinogens and prevention by polyphenols" @default.
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