Matches in SemOpenAlex for { <https://semopenalex.org/work/W2230980915> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2230980915 abstract "To facilitate ground-based microgravity analogue studies, NASA developed high aspect ratio vessels (HARVs) which model low-shear microgravity conditions (LSMMG). To investigate how LSMMG affects global transcriptional activity in opportunistic bacterial pathogens, DNA microarray analysis was carried out on Streptococcus pneumoniae grown in HARVs under LSMMG and compared to 1 x g and static conditions. Analysis of the array data was carried out using multiple analysis methods (Genepix Pro 6.0, Spotfire 7.3, SAM, and ANOVA). SAM analysis revealed 138 significant LSMMG-responsive genes. Among the responsive genes (threshold = 1.5-fold), 81 genes representing different functional groups were down-regulated under LSMMG. Distinct expression patterns were revealed using hierarchical clustering methods (Cluster/Treeview, CLUSFAVOR 6.0, and Spotfire 7.3). Quantitative RT-PCR was used to confirm gene expression changes. Computational analyses revealed 101 genes which were differentially expressed under static versus 1 x g conditions. Among these genes, 46 were altered between 1 x g and LSMMG conditions while 9 were altered between static and LSMMG conditions. SAM analysis revealed 147 genes which exhibited significant changes between static and 1 x g groups. These results indicate LSMMG represents a unique environment which can alter the transcriptional profile and subsequent physiology of bacteria. Further, differences in gene expression between the static and 1 x g controls clearly impact the analysis and must be taken into consideration in the assignment of LSMMG responsive genes." @default.
- W2230980915 created "2016-06-24" @default.
- W2230980915 creator A5001863769 @default.
- W2230980915 creator A5006470384 @default.
- W2230980915 creator A5018398198 @default.
- W2230980915 creator A5024831931 @default.
- W2230980915 creator A5060490380 @default.
- W2230980915 creator A5063066584 @default.
- W2230980915 date "2007-05-07" @default.
- W2230980915 modified "2023-09-28" @default.
- W2230980915 title "A GLOBAL TRANSCRIPTIONAL ANALYSIS OF STREPTOCOCCUS PNEUMONIAE IN RESPONSE TO LOW-SHEAR MODELED MICROGRAVITY" @default.
- W2230980915 cites W1485205881 @default.
- W2230980915 cites W2030308486 @default.
- W2230980915 cites W2097012953 @default.
- W2230980915 cites W2156637499 @default.
- W2230980915 hasPublicationYear "2007" @default.
- W2230980915 type Work @default.
- W2230980915 sameAs 2230980915 @default.
- W2230980915 citedByCount "0" @default.
- W2230980915 crossrefType "journal-article" @default.
- W2230980915 hasAuthorship W2230980915A5001863769 @default.
- W2230980915 hasAuthorship W2230980915A5006470384 @default.
- W2230980915 hasAuthorship W2230980915A5018398198 @default.
- W2230980915 hasAuthorship W2230980915A5024831931 @default.
- W2230980915 hasAuthorship W2230980915A5060490380 @default.
- W2230980915 hasAuthorship W2230980915A5063066584 @default.
- W2230980915 hasConcept C104317684 @default.
- W2230980915 hasConcept C119857082 @default.
- W2230980915 hasConcept C150194340 @default.
- W2230980915 hasConcept C153911025 @default.
- W2230980915 hasConcept C18431079 @default.
- W2230980915 hasConcept C186836561 @default.
- W2230980915 hasConcept C23085057 @default.
- W2230980915 hasConcept C2779018089 @default.
- W2230980915 hasConcept C2781253189 @default.
- W2230980915 hasConcept C41008148 @default.
- W2230980915 hasConcept C523546767 @default.
- W2230980915 hasConcept C54355233 @default.
- W2230980915 hasConcept C73555534 @default.
- W2230980915 hasConcept C8415881 @default.
- W2230980915 hasConcept C86803240 @default.
- W2230980915 hasConcept C92835128 @default.
- W2230980915 hasConceptScore W2230980915C104317684 @default.
- W2230980915 hasConceptScore W2230980915C119857082 @default.
- W2230980915 hasConceptScore W2230980915C150194340 @default.
- W2230980915 hasConceptScore W2230980915C153911025 @default.
- W2230980915 hasConceptScore W2230980915C18431079 @default.
- W2230980915 hasConceptScore W2230980915C186836561 @default.
- W2230980915 hasConceptScore W2230980915C23085057 @default.
- W2230980915 hasConceptScore W2230980915C2779018089 @default.
- W2230980915 hasConceptScore W2230980915C2781253189 @default.
- W2230980915 hasConceptScore W2230980915C41008148 @default.
- W2230980915 hasConceptScore W2230980915C523546767 @default.
- W2230980915 hasConceptScore W2230980915C54355233 @default.
- W2230980915 hasConceptScore W2230980915C73555534 @default.
- W2230980915 hasConceptScore W2230980915C8415881 @default.
- W2230980915 hasConceptScore W2230980915C86803240 @default.
- W2230980915 hasConceptScore W2230980915C92835128 @default.
- W2230980915 hasIssue "2" @default.
- W2230980915 hasLocation W22309809151 @default.
- W2230980915 hasOpenAccess W2230980915 @default.
- W2230980915 hasPrimaryLocation W22309809151 @default.
- W2230980915 hasRelatedWork W1591770463 @default.
- W2230980915 hasRelatedWork W1969544396 @default.
- W2230980915 hasRelatedWork W1976776754 @default.
- W2230980915 hasRelatedWork W2017910415 @default.
- W2230980915 hasRelatedWork W2026781850 @default.
- W2230980915 hasRelatedWork W2098570840 @default.
- W2230980915 hasRelatedWork W2158701760 @default.
- W2230980915 hasRelatedWork W2336885251 @default.
- W2230980915 hasRelatedWork W2367282779 @default.
- W2230980915 hasRelatedWork W2579907646 @default.
- W2230980915 hasRelatedWork W262555347 @default.
- W2230980915 hasRelatedWork W2746296828 @default.
- W2230980915 hasRelatedWork W2774450395 @default.
- W2230980915 hasRelatedWork W2896882542 @default.
- W2230980915 hasRelatedWork W2945067712 @default.
- W2230980915 hasRelatedWork W3002403422 @default.
- W2230980915 hasRelatedWork W3143144810 @default.
- W2230980915 hasRelatedWork W3151744297 @default.
- W2230980915 hasRelatedWork W2139013305 @default.
- W2230980915 hasRelatedWork W2294064772 @default.
- W2230980915 hasVolume "19" @default.
- W2230980915 isParatext "false" @default.
- W2230980915 isRetracted "false" @default.
- W2230980915 magId "2230980915" @default.
- W2230980915 workType "article" @default.