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- W2231133863 abstract "The term “tissue selectivity” is used for an agent showing varying degrees of potency between tissues, with a preferential action in a given one. Tissue selectivity is well-known in the field of α-adrenoceptors, where α1- and α2-agonists and antagonists differ by the ratio of activity at the level of a given tissue. Usually, this is related to their respective affinities for α1- and α2-adrenoceptors. Selectivity is not equivalent to specificity, which refers to a given agent interacting with only one type of receptor. This interaction has been documented mainly in the field of histaminergic receptors, where H1-antagonists do not interact with H2-receptors and vice versa. A question that has been raised several times [18, 19] is the existence of tissue selectivity for calcium antagonists. In other words, does any selectivity exist in the pharmacology of calcium channels? Several factors may be involved in tissue selectivity as reported in Table 1. We do not intend to review each of those factors for every compounds, which would be impossible because all have not been submitted to extensive studies. Nevertheless, some examples need to be given." @default.
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- W2231133863 date "2004-01-01" @default.
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- W2231133863 title "The tissue selectivity of calcium antagonists" @default.
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- W2231133863 doi "https://doi.org/10.1007/978-3-0348-7859-3_4" @default.
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