Matches in SemOpenAlex for { <https://semopenalex.org/work/W2231153305> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2231153305 abstract "The reaction between 5′-deoxyadenosylcobinamide (AdoCbi+OH−) and cyanide (NaCN or tetrabutylammonium cyanide) to form dicyanocobinamide, adenine and 1-cyano-D-erythro-2,3-dihydroxy-4-pentenol has been studied by 1H NMR and UV-visible spectroscopies in aqueous solution at pH (pD) 11.0 and in 92%N,N-dimethylformamide (DMF)–8% D2O. Saturation kinetics are observed by UV-visible spectroscopy at high cyanide concentrations and data were fitted to a mechanism involving rapid formation of an (β-adenosyl)(α-cyano)cobinamide intermediate, (β-Ado)(α-CN)Cbi (KCN= 5.6 (H2O) and 6.9 M−1 (D2O), 25.0 °C, I= 1.0 M (NaClO4); KCN= 4.6 (H2O) and 3.8 M−1 (D2O), 25.0 °C, I=2.0 M (NaClO4), KCN= 2.8 × 103 M−1, 25.0 °C, I= 0.50 M ((TBA)ClO4)), followed by solvent-assisted, rate-determining cleavage of the Co–Ado bond of (β-Ado)(α-CN)Cbi (102k2= 2.91 (H2O) and 2.17 s−1 (D2O), 25.0 °C, I= 1.0 M (NaClO4); 102k2= 2.55 (H2O) and 2.45 s−1 (D2O), 25.0 °C, I= 2.0 M (NaClO4), 105k2= 6.7 s−1, 92% DMF–8% D2O, 25.0 °C, I= 0.50 M ((TBA)ClO4)). Deviations in the plots of the observed rate constant versus cyanide concentration in aqueous solution at high cyanide concentrations is attributed to medium effects, andonly CN−, not HCN, reacts with AdoCbiOH. Evidence for rapid formation of (β-adenosyl)(α-cyano)cobinamide from AdoCbiOH plus cyanide is also obtained by investigating the 1H NMR chemical shifts of the signals in the aromatic region immediately after mixing AdoCbiOH and cyanide as a function of cyanide concentration (D2O, 25.0 °C; KCN′= 5.7 and 3.3 M−1 at I= 1.0 (NaClO4) and 2.0 M (NaClO4), respectively). A comparison of rate and equilibria constants for the reaction between AdoCbiOH and 5′-deoxyadenosylcobalamin is made." @default.
- W2231153305 created "2016-06-24" @default.
- W2231153305 creator A5037330369 @default.
- W2231153305 creator A5047722492 @default.
- W2231153305 creator A5091484015 @default.
- W2231153305 date "2002-01-01" @default.
- W2231153305 modified "2023-09-27" @default.
- W2231153305 title "Studies on the mechanism of the reaction between 5-deoxyadenosylcobinamide and cyanide." @default.
- W2231153305 hasPublicationYear "2002" @default.
- W2231153305 type Work @default.
- W2231153305 sameAs 2231153305 @default.
- W2231153305 citedByCount "0" @default.
- W2231153305 crossrefType "journal-article" @default.
- W2231153305 hasAuthorship W2231153305A5037330369 @default.
- W2231153305 hasAuthorship W2231153305A5047722492 @default.
- W2231153305 hasAuthorship W2231153305A5091484015 @default.
- W2231153305 hasConcept C121332964 @default.
- W2231153305 hasConcept C148898269 @default.
- W2231153305 hasConcept C155647269 @default.
- W2231153305 hasConcept C178790620 @default.
- W2231153305 hasConcept C179104552 @default.
- W2231153305 hasConcept C184651966 @default.
- W2231153305 hasConcept C185592680 @default.
- W2231153305 hasConcept C2777712214 @default.
- W2231153305 hasConcept C2778455166 @default.
- W2231153305 hasConcept C2780471494 @default.
- W2231153305 hasConcept C62520636 @default.
- W2231153305 hasConcept C93391505 @default.
- W2231153305 hasConceptScore W2231153305C121332964 @default.
- W2231153305 hasConceptScore W2231153305C148898269 @default.
- W2231153305 hasConceptScore W2231153305C155647269 @default.
- W2231153305 hasConceptScore W2231153305C178790620 @default.
- W2231153305 hasConceptScore W2231153305C179104552 @default.
- W2231153305 hasConceptScore W2231153305C184651966 @default.
- W2231153305 hasConceptScore W2231153305C185592680 @default.
- W2231153305 hasConceptScore W2231153305C2777712214 @default.
- W2231153305 hasConceptScore W2231153305C2778455166 @default.
- W2231153305 hasConceptScore W2231153305C2780471494 @default.
- W2231153305 hasConceptScore W2231153305C62520636 @default.
- W2231153305 hasConceptScore W2231153305C93391505 @default.
- W2231153305 hasLocation W22311533051 @default.
- W2231153305 hasOpenAccess W2231153305 @default.
- W2231153305 hasPrimaryLocation W22311533051 @default.
- W2231153305 hasRelatedWork W1848057535 @default.
- W2231153305 hasRelatedWork W1973290346 @default.
- W2231153305 hasRelatedWork W1977438444 @default.
- W2231153305 hasRelatedWork W1997028619 @default.
- W2231153305 hasRelatedWork W1997147487 @default.
- W2231153305 hasRelatedWork W1999227480 @default.
- W2231153305 hasRelatedWork W2017885109 @default.
- W2231153305 hasRelatedWork W2028962994 @default.
- W2231153305 hasRelatedWork W2030746926 @default.
- W2231153305 hasRelatedWork W2065930006 @default.
- W2231153305 hasRelatedWork W2082359740 @default.
- W2231153305 hasRelatedWork W2083253605 @default.
- W2231153305 hasRelatedWork W2084132731 @default.
- W2231153305 hasRelatedWork W2086789414 @default.
- W2231153305 hasRelatedWork W2094343638 @default.
- W2231153305 hasRelatedWork W2158744263 @default.
- W2231153305 hasRelatedWork W2326570679 @default.
- W2231153305 hasRelatedWork W2560890717 @default.
- W2231153305 hasRelatedWork W2949835524 @default.
- W2231153305 hasRelatedWork W2952125487 @default.
- W2231153305 isParatext "false" @default.
- W2231153305 isRetracted "false" @default.
- W2231153305 magId "2231153305" @default.
- W2231153305 workType "article" @default.