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• W2231247051 abstract "7567 Background: Lung CT imaging shows promise for early lung cancer detection, but may be insensitive for central lesions and will create a need for complementary biomarkers to guide clinical decisions. Methods: We have been conducting a prospective study to assess the performance of various biomarkers in sputum to detect lung cancer. Within a cohort of 3,269 people at high risk for lung cancer (over 30 pack-years of cigarette use and chronic obstructive lung disease) we have conducted a nested case-control study to assay stored samples from 85 incident lung cancer cases and 73 controls for cytologic morphology, DNA methylation, and multi-targeted FISH assays (LAVysion, Vysis/Abbott Molecular). The FISH assay targeted DNA sequences from centromere 6, 5p15.2, 7p12 (EGFR), and 8q24 (cMYC). Cytology was classified as abnormal if moderate or greater atypia was observed, methylation was abnormal if three or more of 8 selected genes were methylated, and FISH was abnormal if two or more scored cells were observed to contain chromosomal aneuploidy indicated by signal gain for at least two targets or signal gain for one and signal loss for two or more targets. Results: Among all subjects, regardless of the time between sputum collection and diagnosis, FISH was abnormal in 49/87 cases (56%) and 5/73 controls (7%) (odds ratio (OR) = 17.5, 95% CI = 6.4 to 47.8). Considering only the cases for which sputum had been collected within 18 months before the lung cancer diagnosis, FISH was abnormal in 37/49 cases (75%) and in 3/38 controls (8%) (OR = 36.0, 95% CI = 9.4 to 138). For this same time period, cytological atypia was abnormal in 37% of cases and 22% of controls (OR = 2.1, 95% CI = 0.8 to 5.3) and methylation was abnormal in 64% of cases and 36% of controls (OR = 4.5, 95% CI = 1.0 to 19.8). Conclusions: The LAVysion FISH assay is more sensitive than other currently available sputum tests for the prediction of invasive carcinoma in subjects and is highly specific with a low frequency of false positive and false negative results. The results suggest that chromosomal aneuploidy and by extrapolation, missegregation, are features of advanced premalignancy and should identify patients who are proximate to clinically overt lung cancer. [Table: see text]" @default.
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• W2231247051 date "2007-06-20" @default.
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• W2231247051 title "FISHing for lung cancer: Promising findings using multi-targeted interphase fluorescence in situ hybridization (FISH) for lung cancer detection in sputum" @default.
• W2231247051 doi "https://doi.org/10.1200/jco.2007.25.18_suppl.7567" @default.
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